ARHGAP1

Rho GTPase activating protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
small GTPase mediated signal transduction [GO:0007264],
Rho protein signal transduction [GO:0007266],
endosomal transport [GO:0016197],
transferrin transport [GO:0033572],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],
negative regulation of endocytic recycling [GO:2001136],
signal transduction [GO:0007165],
regulation of GTPase activity [GO:0043087],

Molecular Function:
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
SH3 domain binding [GO:0017124],
Rab GTPase binding [GO:0017137],
cadherin binding [GO:0045296],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
endosome membrane [GO:0010008],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
sorting endosome [GO:0097443],
ruffle [GO:0001726],
plasma membrane [GO:0005886],
cell leading edge [GO:0031252],