LIPA

lipase A, lysosomal acid type

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
cell morphogenesis [GO:0000902],
cytokine production [GO:0001816],
inflammatory response [GO:0006954],
cell proliferation [GO:0008283],
lipid catabolic process [GO:0016042],
sterol metabolic process [GO:0016125],
lung development [GO:0030324],
low-density lipoprotein particle clearance [GO:0034383],
tissue remodeling [GO:0048771],
homeostasis of number of cells within a tissue [GO:0048873],
lipid metabolic process [GO:0006629],
fatty acid metabolic process [GO:0006631],

Molecular Function:
sterol esterase activity [GO:0004771],
lipase activity [GO:0016298],
hydrolase activity [GO:0016787],
hydrolase activity, acting on ester bonds [GO:0016788],

Cellular Component:
fibrillar center [GO:0001650],
lysosome [GO:0005764],
lysosomal lumen [GO:0043202],
intracellular membrane-bounded organelle [GO:0043231],