DNA ligase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
DNA ligation [GO:0006266],
lagging strand elongation [GO:0006273],
DNA repair [GO:0006281],
transcription-coupled nucleotide-excision repair [GO:0006283],
base-excision repair [GO:0006284],
nucleotide-excision repair, DNA gap filling [GO:0006297],
mismatch repair [GO:0006298],
anatomical structure morphogenesis [GO:0009653],
V(D)J recombination [GO:0033151],
DNA ligation involved in DNA repair [GO:0051103],
cell division [GO:0051301],
DNA biosynthetic process [GO:0071897],
Okazaki fragment processing involved in mitotic DNA replication [GO:1903461],
DNA replication [GO:0006260],
double-strand break repair via nonhomologous end joining [GO:0006303],
DNA recombination [GO:0006310],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
response to hydrogen peroxide [GO:0042542],

Molecular Function:
DNA binding [GO:0003677],
DNA ligase activity [GO:0003909],
DNA ligase (ATP) activity [GO:0003910],
ATP binding [GO:0005524],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
ligase activity [GO:0016874],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
intracellular membrane-bounded organelle [GO:0043231],