LIF

LIF interleukin 6 family cytokine

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31183403 IMR-90 Human YES
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES
31945125 Primary astrocytes derived from brain Human YES
31971661 Primary mesenchymal stem cells derived from adipose tissue Mouse YES
33470505 brain Mouse No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
30977188 MSC Human YES

GO terms:

Biological Process:
blood vessel remodeling [GO:0001974],
immune response [GO:0006955],
tyrosine phosphorylation of STAT protein [GO:0007260],
multicellular organism development [GO:0007275],
embryo implantation [GO:0007566],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
cytokine-mediated signaling pathway [GO:0019221],
stem cell population maintenance [GO:0019827],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141],
positive regulation of cell adhesion mediated by integrin [GO:0033630],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
positive regulation of MAPK cascade [GO:0043410],
regulation of cell differentiation [GO:0045595],
positive regulation of macrophage differentiation [GO:0045651],
negative regulation of meiotic nuclear division [GO:0045835],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
decidualization [GO:0046697],
negative regulation of hormone secretion [GO:0046888],
lung alveolus development [GO:0048286],
muscle organ morphogenesis [GO:0048644],
neuron development [GO:0048666],
positive regulation of astrocyte differentiation [GO:0048711],
leukemia inhibitory factor signaling pathway [GO:0048861],
stem cell differentiation [GO:0048863],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
lung vasculature development [GO:0060426],
lung lobe morphogenesis [GO:0060463],
trophoblast giant cell differentiation [GO:0060707],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108],
regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307],
positive regulation of protein localization to nucleus [GO:1900182],
positive regulation of histone H3-K27 acetylation [GO:1901676],
regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903025],
positive regulation of gene expression [GO:0010628],
positive regulation of neuron projection development [GO:0010976],
negative regulation of angiogenesis [GO:0016525],
lung development [GO:0030324],
animal organ regeneration [GO:0031100],
astrocyte differentiation [GO:0048708],
positive regulation of corticotropin secretion [GO:0051461],
retina development in camera-type eye [GO:0060041],
maternal process involved in female pregnancy [GO:0060135],
transdifferentiation [GO:0060290],
spongiotrophoblast differentiation [GO:0060708],

Molecular Function:
receptor binding [GO:0005102],
cytokine activity [GO:0005125],
leukemia inhibitory factor receptor binding [GO:0005146],
protein binding [GO:0005515],
growth factor activity [GO:0008083],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytosol [GO:0005829],