LGR4

leucine rich repeat containing G protein-coupled receptor 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
osteoblast differentiation [GO:0001649],
hair follicle development [GO:0001942],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
activation of adenylate cyclase activity [GO:0007190],
spermatogenesis [GO:0007283],
hormone-mediated signaling pathway [GO:0009755],
bone mineralization [GO:0030282],
male genitalia development [GO:0030539],
circadian regulation of gene expression [GO:0032922],
negative regulation of toll-like receptor signaling pathway [GO:0034122],
intestinal stem cell homeostasis [GO:0036335],
innate immune response [GO:0045087],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
bone remodeling [GO:0046849],
digestive tract development [GO:0048565],
negative regulation of cytokine secretion [GO:0050710],
canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290],
cell differentiation involved in metanephros development [GO:0072202],
metanephric glomerulus development [GO:0072224],
metanephric nephron tubule morphogenesis [GO:0072282],
positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013],
immune system process [GO:0002376],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
multicellular organism development [GO:0007275],
axon guidance [GO:0007411],
circadian rhythm [GO:0007623],
Wnt signaling pathway [GO:0016055],
cell differentiation [GO:0030154],
tube morphogenesis [GO:0035239],
rhythmic process [GO:0048511],
epithelial cell proliferation [GO:0050673],
negative chemotaxis [GO:0050919],

Molecular Function:
transmembrane signaling receptor activity [GO:0004888],
G-protein coupled receptor activity [GO:0004930],
protein binding [GO:0005515],
G-protein coupled peptide receptor activity [GO:0008528],
protein-hormone receptor activity [GO:0016500],
heparin binding [GO:0008201],
Roundabout binding [GO:0048495],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
integral component of membrane [GO:0016021],