ARFGEF family member 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA437 Skin, Lung Human YES
29548335 Saos-2 Human YES
30988157 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
negative regulation of phosphatase activity [GO:0010923],
actin cytoskeleton organization [GO:0030036],
regulation of ARF protein signal transduction [GO:0032012],

Molecular Function:
ARF guanyl-nucleotide exchange factor activity [GO:0005086],
guanyl-nucleotide exchange factor activity [GO:0005085],

Cellular Component:
integral component of membrane [GO:0016021],
transport vesicle membrane [GO:0030658],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],