ARFGEF2

ADP ribosylation factor guanine nucleotide exchange factor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
receptor recycling [GO:0001881],
exocytosis [GO:0006887],
Golgi to plasma membrane transport [GO:0006893],
endosome organization [GO:0007032],
endomembrane system organization [GO:0010256],
protein transport [GO:0015031],
regulation of ARF protein signal transduction [GO:0032012],
positive regulation of tumor necrosis factor production [GO:0032760],
intracellular signal transduction [GO:0035556],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
ARF guanyl-nucleotide exchange factor activity [GO:0005086],
protein binding [GO:0005515],
myosin binding [GO:0017022],
protein kinase A regulatory subunit binding [GO:0034237],
GABA receptor binding [GO:0050811],

Cellular Component:
Golgi membrane [GO:0000139],
trans-Golgi network [GO:0005802],
microtubule organizing center [GO:0005815],
cytosol [GO:0005829],
axonemal microtubule [GO:0005879],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
asymmetric synapse [GO:0032279],
symmetric synapse [GO:0032280],
dendritic spine [GO:0043197],
perinuclear region of cytoplasm [GO:0048471],
recycling endosome [GO:0055037],
cytoplasm [GO:0005737],
endosome [GO:0005768],
Golgi apparatus [GO:0005794],
cytoskeleton [GO:0005856],
cell junction [GO:0030054],
cell projection [GO:0042995],
synapse [GO:0045202],