LEPR

leptin receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30977188 MSC Human YES
31543366 WA09 Brain Human, mouse YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
positive regulation of protein phosphorylation [GO:0001934],
glycogen metabolic process [GO:0005977],
energy reserve metabolic process [GO:0006112],
phagocytosis [GO:0006909],
cell surface receptor signaling pathway [GO:0007166],
multicellular organism development [GO:0007275],
cholesterol metabolic process [GO:0008203],
negative regulation of autophagy [GO:0010507],
glial cell proliferation [GO:0014009],
cytokine-mediated signaling pathway [GO:0019221],
sexual reproduction [GO:0019953],
T cell differentiation [GO:0030217],
leptin-mediated signaling pathway [GO:0033210],
glucose homeostasis [GO:0042593],
response to leptin [GO:0044321],
negative regulation of gluconeogenesis [GO:0045721],
regulation of bone remodeling [GO:0046850],
regulation of transport [GO:0051049],
negative regulation of hydrolase activity [GO:0051346],
regulation of feeding behavior [GO:0060259],
energy homeostasis [GO:0097009],
bone growth [GO:0098868],
signal transduction [GO:0007165],
regulation of metabolic process [GO:0019222],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
eating behavior [GO:0042755],
positive regulation of MAPK cascade [GO:0043410],
negative regulation of eating behavior [GO:1903999],
negative regulation of locomotor rhythm [GO:1904060],

Molecular Function:
transmembrane signaling receptor activity [GO:0004888],
cytokine receptor activity [GO:0004896],
protein binding [GO:0005515],
peptide hormone binding [GO:0017046],
cytokine binding [GO:0019955],
leptin receptor activity [GO:0038021],
identical protein binding [GO:0042802],
protein-hormone receptor activity [GO:0016500],

Cellular Component:
extracellular region [GO:0005576],
external side of plasma membrane [GO:0009897],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
receptor complex [GO:0043235],
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],