LEP

leptin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25989537 Primary stem cells derived from mesenchyma Human NO
30977188 MSC Human YES
31543366 Brain Mouse YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31543366 WA09 Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
angiogenesis [GO:0001525],
ovulation from ovarian follicle [GO:0001542],
response to hypoxia [GO:0001666],
placenta development [GO:0001890],
positive regulation of protein phosphorylation [GO:0001934],
regulation of endothelial cell proliferation [GO:0001936],
response to dietary excess [GO:0002021],
cardiac muscle hypertrophy [GO:0003300],
glucose metabolic process [GO:0006006],
regulation of gluconeogenesis [GO:0006111],
energy reserve metabolic process [GO:0006112],
glycerol biosynthetic process [GO:0006114],
lipid metabolic process [GO:0006629],
fatty acid beta-oxidation [GO:0006635],
phagocytosis [GO:0006909],
tyrosine phosphorylation of STAT protein [GO:0007260],
female pregnancy [GO:0007565],
circadian rhythm [GO:0007623],
cholesterol metabolic process [GO:0008203],
bile acid metabolic process [GO:0008206],
regulation of blood pressure [GO:0008217],
determination of adult lifespan [GO:0008340],
adult feeding behavior [GO:0008343],
negative regulation of autophagy [GO:0010507],
negative regulation of lipid storage [GO:0010888],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
response to activity [GO:0014823],
sexual reproduction [GO:0019953],
central nervous system neuron development [GO:0021954],
insulin secretion [GO:0030073],
T cell differentiation [GO:0030217],
regulation of intestinal cholesterol absorption [GO:0030300],
positive regulation of TOR signaling [GO:0032008],
negative regulation of appetite [GO:0032099],
prostaglandin secretion [GO:0032310],
response to estradiol [GO:0032355],
interleukin-12 production [GO:0032615],
positive regulation of tumor necrosis factor production [GO:0032760],
regulation of natural killer cell activation [GO:0032814],
regulation of natural killer cell proliferation [GO:0032817],
response to insulin [GO:0032868],
cellular response to insulin stimulus [GO:0032869],
response to vitamin E [GO:0033197],
leptin-mediated signaling pathway [GO:0033210],
positive regulation of luteinizing hormone secretion [GO:0033686],
positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360],
intracellular signal transduction [GO:0035556],
bone mineralization involved in bone maturation [GO:0035630],
aorta development [GO:0035904],
negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108],
positive regulation of T cell proliferation [GO:0042102],
regulation of natural killer cell mediated cytotoxicity [GO:0042269],
positive regulation of protein import into nucleus [GO:0042307],
hormone metabolic process [GO:0042445],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
glucose homeostasis [GO:0042593],
eating behavior [GO:0042755],
negative regulation of apoptotic process [GO:0043066],
positive regulation of ion transport [GO:0043270],
positive regulation of MAPK cascade [GO:0043410],
cellular response to leptin stimulus [GO:0044320],
response to ethanol [GO:0045471],
regulation of angiogenesis [GO:0045765],
negative regulation of vasoconstriction [GO:0045906],
negative regulation of glucose import [GO:0046325],
positive regulation of JAK-STAT cascade [GO:0046427],
positive regulation of insulin receptor signaling pathway [GO:0046628],
regulation of bone remodeling [GO:0046850],
positive regulation of follicle-stimulating hormone secretion [GO:0046881],
positive regulation of developmental growth [GO:0048639],
regulation of insulin secretion [GO:0050796],
regulation of steroid biosynthetic process [GO:0050810],
intestinal absorption [GO:0050892],
leukocyte tethering or rolling [GO:0050901],
regulation of nitric-oxide synthase activity [GO:0050999],
elastin metabolic process [GO:0051541],
regulation of cell cycle [GO:0051726],
positive regulation of protein kinase B signaling [GO:0051897],
regulation of lipoprotein lipid oxidation [GO:0060587],
adipose tissue development [GO:0060612],
negative regulation of cartilage development [GO:0061037],
negative regulation of glucagon secretion [GO:0070093],
cellular response to L-ascorbic acid [GO:0071298],
cellular response to retinoic acid [GO:0071300],
interleukin-6 secretion [GO:0072604],
interleukin-8 secretion [GO:0072606],
regulation of brown fat cell differentiation [GO:0090335],
bone growth [GO:0098868],
regulation of cytokine production involved in inflammatory response [GO:1900015],
positive regulation of p38MAPK cascade [GO:1900745],
positive regulation of fat cell apoptotic process [GO:1904651],
activation of protein kinase C activity [GO:1990051],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
negative regulation of glutamine transport [GO:2000486],
positive regulation of hepatic stellate cell activation [GO:2000491],
regulation of protein phosphorylation [GO:0001932],
signal transduction [GO:0007165],
positive regulation of cell proliferation [GO:0008284],
fatty acid catabolic process [GO:0009062],
negative regulation of metabolic process [GO:0009892],
regulation of metabolic process [GO:0019222],
interleukin-6 production [GO:0032635],
regulation of fat cell differentiation [GO:0045598],
positive regulation of myeloid cell differentiation [GO:0045639],
regulation of lipid biosynthetic process [GO:0046890],
regulation of catalytic activity [GO:0050790],
regulation of protein localization to nucleus [GO:1900180],

Molecular Function:
DNA binding [GO:0003677],
hormone activity [GO:0005179],
peptide hormone receptor binding [GO:0051428],
leptin receptor binding [GO:1990460],
receptor binding [GO:0005102],
protein binding [GO:0005515],
growth factor activity [GO:0008083],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytosol [GO:0005829],
cytoplasm [GO:0005737],