LDB1

LIM domain binding 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972],
transcription, DNA-templated [GO:0006351],
regulation of transcription, DNA-templated [GO:0006355],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
neuron differentiation [GO:0030182],
regulation of cell migration [GO:0030334],
regulation of DNA-templated transcription, elongation [GO:0032784],
regulation of kinase activity [GO:0043549],
histone H3-K4 acetylation [GO:0043973],
negative regulation of erythrocyte differentiation [GO:0045647],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of hemoglobin biosynthetic process [GO:0046985],
regulation of focal adhesion assembly [GO:0051893],
regulation of hematopoietic stem cell differentiation [GO:1902036],
gastrulation with mouth forming second [GO:0001702],
hair follicle development [GO:0001942],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription from RNA polymerase II promoter [GO:0006366],
anterior/posterior axis specification [GO:0009948],
epithelial structure maintenance [GO:0010669],
Wnt signaling pathway [GO:0016055],
cerebellum development [GO:0021549],
cerebellar Purkinje cell differentiation [GO:0021702],
cellular component assembly [GO:0022607],
cell differentiation [GO:0030154],
somatic stem cell population maintenance [GO:0035019],
positive regulation of cell adhesion [GO:0045785],
mesendoderm development [GO:0048382],
primitive erythrocyte differentiation [GO:0060319],
head development [GO:0060322],

Molecular Function:
RNA polymerase II activating transcription factor binding [GO:0001102],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
enzyme binding [GO:0019899],
LIM domain binding [GO:0030274],
protein homodimerization activity [GO:0042803],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
transcription cofactor activity [GO:0003712],
identical protein binding [GO:0042802],
protein self-association [GO:0043621],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cell leading edge [GO:0031252],
macromolecular complex [GO:0032991],
beta-catenin-TCF complex [GO:1990907],