ARF6

ADP ribosylation factor 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
liver development [GO:0001889],
intracellular protein transport [GO:0006886],
cell cycle [GO:0007049],
cell adhesion [GO:0007155],
vesicle-mediated transport [GO:0016192],
positive regulation of actin filament polymerization [GO:0030838],
cortical actin cytoskeleton organization [GO:0030866],
endocytic recycling [GO:0032456],
myeloid cell apoptotic process [GO:0033028],
protein localization to cell surface [GO:0034394],
regulation of Rac protein signal transduction [GO:0035020],
protein localization to endosome [GO:0036010],
negative regulation of receptor-mediated endocytosis [GO:0048261],
synaptic vesicle endocytosis [GO:0048488],
positive regulation of protein secretion [GO:0050714],
cell division [GO:0051301],
regulation of filopodium assembly [GO:0051489],
positive regulation of keratinocyte migration [GO:0051549],
regulation of dendritic spine development [GO:0060998],
establishment of epithelial cell polarity [GO:0090162],
ruffle assembly [GO:0097178],
hepatocyte apoptotic process [GO:0097284],
maintenance of postsynaptic density structure [GO:0099562],
positive regulation of protein localization to plasma membrane [GO:1903078],
cellular response to nerve growth factor stimulus [GO:1990090],
negative regulation of protein localization to cell surface [GO:2000009],
negative regulation of dendrite development [GO:2000171],
nervous system development [GO:0007399],
regulation of neuron projection development [GO:0010975],
protein transport [GO:0015031],
cell differentiation [GO:0030154],
regulation of toll-like receptor 4 signaling pathway [GO:0034143],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
thioesterase binding [GO:0031996],
protein N-terminus binding [GO:0047485],
nucleotide binding [GO:0000166],

Cellular Component:
ruffle [GO:0001726],
cytoplasm [GO:0005737],
endosome [GO:0005768],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cell cortex [GO:0005938],
membrane [GO:0016020],
endocytic vesicle [GO:0030139],
filopodium membrane [GO:0031527],
early endosome membrane [GO:0031901],
cleavage furrow [GO:0032154],
recycling endosome membrane [GO:0055038],
extracellular exosome [GO:0070062],
Flemming body [GO:0090543],
presynapse [GO:0098793],
glutamatergic synapse [GO:0098978],
early endosome [GO:0005769],
cell projection [GO:0042995],
myelin sheath [GO:0043209],
recycling endosome [GO:0055037],