ADP ribosylation factor 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein ADP-ribosylation [GO:0006471],
intracellular protein transport [GO:0006886],
ER to Golgi vesicle-mediated transport [GO:0006888],
retrograde vesicle-mediated transport, Golgi to ER [GO:0006890],
epidermal growth factor receptor signaling pathway [GO:0007173],
brain development [GO:0007420],
learning [GO:0007612],
vesicle-mediated transport [GO:0016192],
cell migration [GO:0016477],
activation of phospholipase D activity [GO:0031584],
negative regulation of apoptotic process [GO:0043066],
apical protein localization [GO:0045176],
establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
response to axon injury [GO:0048678],
dendritic spine development [GO:0060996],
protein localization to cilium [GO:0061512],
regulation of reactive oxygen species metabolic process [GO:2000377],
protein transport [GO:0015031],
regulation of synapse organization [GO:0050807],

Molecular Function:
GTPase activity [GO:0003924],
ARF guanyl-nucleotide exchange factor activity [GO:0005086],
epidermal growth factor receptor binding [GO:0005154],
protein binding [GO:0005515],
GTP binding [GO:0005525],
nucleotide binding [GO:0000166],

Cellular Component:
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
ruffle membrane [GO:0032587],
dendritic spine [GO:0043197],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],