large tumor suppressor kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19855428 WI-38 Human NO
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
21498571 IMR-90, hTERT-RPE-1, HEK 293, SAOS Human NO
31945054 IMR-90 Human YES

GO terms:

Biological Process:
G1/S transition of mitotic cell cycle [GO:0000082],
protein phosphorylation [GO:0006468],
hormone-mediated signaling pathway [GO:0009755],
peptidyl-serine phosphorylation [GO:0018105],
hippo signaling [GO:0035329],
intracellular signal transduction [GO:0035556],
positive regulation of apoptotic process [GO:0043065],
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736],
regulation of organ growth [GO:0046620],
cell division [GO:0051301],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
inner cell mass cell fate commitment [GO:0001827],
inner cell mass cellular morphogenesis [GO:0001828],
cell cycle [GO:0007049],
phosphorylation [GO:0016310],
keratinocyte differentiation [GO:0030216],
cellular protein localization [GO:0034613],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
spindle pole [GO:0000922],
nucleus [GO:0005634],
cytosol [GO:0005829],
centriolar satellite [GO:0034451],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],