large tumor suppressor kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27358050 MEF, Primary cells derived from liver Human, mouse NO
32991321 C6 ATCC Human NO

GO terms:

Biological Process:
G1/S transition of mitotic cell cycle [GO:0000082],
G2/M transition of mitotic cell cycle [GO:0000086],
sister chromatid segregation [GO:0000819],
inner cell mass cell fate commitment [GO:0001827],
inner cell mass cellular morphogenesis [GO:0001828],
protein phosphorylation [GO:0006468],
hormone-mediated signaling pathway [GO:0009755],
peptidyl-serine phosphorylation [GO:0018105],
keratinocyte differentiation [GO:0030216],
regulation of actin filament polymerization [GO:0030833],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
regulation of intracellular estrogen receptor signaling pathway [GO:0033146],
cellular protein localization [GO:0034613],
hippo signaling [GO:0035329],
intracellular signal transduction [GO:0035556],
positive regulation of apoptotic process [GO:0043065],
regulation of protein complex assembly [GO:0043254],
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736],
regulation of organ growth [GO:0046620],
cytoplasmic sequestering of protein [GO:0051220],
cell division [GO:0051301],
mammary gland epithelial cell differentiation [GO:0060644],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000058],
mitotic cell cycle [GO:0000278],
cell cycle [GO:0007049],
phosphorylation [GO:0016310],

Molecular Function:
magnesium ion binding [GO:0000287],
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
estrogen receptor binding [GO:0030331],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
spindle pole [GO:0000922],
microtubule organizing center [GO:0005815],
cytosol [GO:0005829],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],