LAMC2

laminin subunit gamma 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
cell adhesion [GO:0007155],
motor neuron axon guidance [GO:0008045],
positive regulation of cell proliferation [GO:0008284],
epidermis development [GO:0008544],
animal organ morphogenesis [GO:0009887],
tissue development [GO:0009888],
dendrite development [GO:0016358],
extracellular matrix organization [GO:0030198],
positive regulation of cell migration [GO:0030335],
hemidesmosome assembly [GO:0031581],

Molecular Function:
receptor binding [GO:0005102],
extracellular matrix structural constituent [GO:0005201],
heparin binding [GO:0008201],
protein binding [GO:0005515],

Cellular Component:
extracellular region [GO:0005576],
basement membrane [GO:0005604],
laminin-2 complex [GO:0005607],
extracellular space [GO:0005615],
cell cortex [GO:0005938],
membrane [GO:0016020],
perinuclear region of cytoplasm [GO:0048471],
laminin-5 complex [GO:0005610],
extracellular matrix [GO:0031012],