ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES

GO terms:

Biological Process:
cytoskeleton organization [GO:0007010],
signal transduction [GO:0007165],
vesicle-mediated transport [GO:0016192],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],
regulation of cell shape [GO:0008360],
negative regulation of cell migration [GO:0030336],
negative regulation of Rac protein signal transduction [GO:0035021],
negative regulation of Rho protein signal transduction [GO:0035024],

Molecular Function:
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547],
phosphatidylinositol-3,4-bisphosphate binding [GO:0043325],
metal ion binding [GO:0046872],

Cellular Component:
ruffle [GO:0001726],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
lamellipodium [GO:0030027],
cytoplasm [GO:0005737],
membrane [GO:0016020],
cell projection [GO:0042995],