kinase suppressor of ras 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
16507997 MEF Mouse NO
29548335 Li Fraumeni Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPKKK activity [GO:0000185],
signal transduction [GO:0007165],
Ras protein signal transduction [GO:0007265],
cAMP-mediated signaling [GO:0019933],
regulation of cell proliferation [GO:0042127],
regulation of MAP kinase activity [GO:0043405],
positive regulation of MAPK cascade [GO:0043410],
phosphorylation [GO:0016310],
intracellular signal transduction [GO:0035556],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
MAP-kinase scaffold activity [GO:0005078],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
mitogen-activated protein kinase kinase binding [GO:0031434],
metal ion binding [GO:0046872],
chaperone binding [GO:0051087],
Hsp90 protein binding [GO:0051879],
14-3-3 protein binding [GO:0071889],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],

Cellular Component:
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
membrane [GO:0016020],
ruffle membrane [GO:0032587],
macromolecular complex [GO:0032991],
plasma membrane [GO:0005886],
cell projection [GO:0042995],