keratin 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
viral process [GO:0016032],
keratinization [GO:0031424],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
sarcomere organization [GO:0045214],
response to hydrostatic pressure [GO:0051599],
response to other organism [GO:0051707],
cell differentiation involved in embryonic placenta development [GO:0060706],
cornification [GO:0070268],
extrinsic apoptotic signaling pathway [GO:0097191],
hepatocyte apoptotic process [GO:0097284],
cell morphogenesis involved in differentiation [GO:0000904],
multicellular organism development [GO:0007275],

Molecular Function:
protein binding [GO:0005515],
macromolecular complex binding [GO:0044877],
scaffold protein binding [GO:0097110],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
intermediate filament [GO:0005882],
cell-cell junction [GO:0005911],
dystrophin-associated glycoprotein complex [GO:0016010],
apicolateral plasma membrane [GO:0016327],
nuclear matrix [GO:0016363],
Z disc [GO:0030018],
sarcolemma [GO:0042383],
costamere [GO:0043034],
keratin filament [GO:0045095],
intermediate filament cytoskeleton [GO:0045111],
extracellular exosome [GO:0070062],
cell periphery [GO:0071944],