AR

androgen receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
22403609 PC-3, LNCaP, RWPE-1 Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
in utero embryonic development [GO:0001701],
regulation of systemic arterial blood pressure [GO:0003073],
epithelial cell morphogenesis [GO:0003382],
transcription, DNA-templated [GO:0006351],
transcription initiation from RNA polymerase II promoter [GO:0006367],
signal transduction [GO:0007165],
cell-cell signaling [GO:0007267],
spermatogenesis [GO:0007283],
single fertilization [GO:0007338],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
positive regulation of gene expression [GO:0010628],
protein deubiquitination [GO:0016579],
male somatic sex determination [GO:0019102],
androgen receptor signaling pathway [GO:0030521],
intracellular receptor signaling pathway [GO:0030522],
positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148],
Leydig cell differentiation [GO:0033327],
multicellular organism growth [GO:0035264],
positive regulation of phosphorylation [GO:0042327],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568],
positive regulation of cell differentiation [GO:0045597],
negative regulation of integrin biosynthetic process [GO:0045720],
positive regulation of integrin biosynthetic process [GO:0045726],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of transcription from RNA polymerase III promoter [GO:0045945],
regulation of developmental growth [GO:0048638],
animal organ formation [GO:0048645],
male genitalia morphogenesis [GO:0048808],
negative regulation of epithelial cell proliferation [GO:0050680],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
activation of prostate induction by androgen receptor signaling pathway [GO:0060520],
morphogenesis of an epithelial fold [GO:0060571],
lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599],
prostate gland growth [GO:0060736],
prostate gland epithelium morphogenesis [GO:0060740],
epithelial cell differentiation involved in prostate gland development [GO:0060742],
tertiary branching involved in mammary gland duct morphogenesis [GO:0060748],
mammary gland alveolus development [GO:0060749],
positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769],
cellular response to steroid hormone stimulus [GO:0071383],
cellular response to testosterone stimulus [GO:0071394],
seminiferous tubule development [GO:0072520],
regulation of protein localization to plasma membrane [GO:1903076],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
copulation [GO:0007620],
male courtship behavior [GO:0008049],
male gonad development [GO:0008584],
fertilization [GO:0009566],
cellular process [GO:0009987],
regulation of gene expression [GO:0010468],
skeletal muscle hypertrophy [GO:0014734],
reproductive behavior [GO:0019098],
negative regulation of transcription, DNA-templated [GO:0045892],
male sex differentiation [GO:0046661],
reproductive structure development [GO:0048608],
positive regulation of penile erection [GO:0060406],
regulation of prostatic bud formation [GO:0060685],
reproductive system development [GO:0061458],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II transcription factor binding [GO:0001085],
RNA polymerase II basal transcription factor binding [GO:0001091],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879],
receptor binding [GO:0005102],
steroid binding [GO:0005496],
androgen binding [GO:0005497],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
transcription factor binding [GO:0008134],
zinc ion binding [GO:0008270],
enzyme binding [GO:0019899],
ATPase binding [GO:0051117],
repressing transcription factor binding [GO:0070491],
POU domain binding [GO:0070974],
DNA binding [GO:0003677],
lipid binding [GO:0008289],
protein domain specific binding [GO:0019904],
ribonucleotide binding [GO:0032553],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],
androgen receptor binding [GO:0050681],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
nuclear speck [GO:0016607],
macromolecular complex [GO:0032991],
host cell nucleus [GO:0042025],
axon [GO:0030424],
dendrite [GO:0030425],