aquaporin 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human NO

GO terms:

Biological Process:
renal water homeostasis [GO:0003091],
water transport [GO:0006833],
cellular water homeostasis [GO:0009992],
water homeostasis [GO:0030104],
multicellular organismal water homeostasis [GO:0050891],
protein homotetramerization [GO:0051289],
transmembrane transport [GO:0055085],
cellular response to interferon-gamma [GO:0071346],
cerebrospinal fluid circulation [GO:0090660],
sensory perception of sound [GO:0007605],
regulation of vascular endothelial growth factor production [GO:0010574],
carbon dioxide transport [GO:0015670],
negative regulation of interleukin-1 beta production [GO:0032691],
negative regulation of interleukin-6 production [GO:0032715],
cerebrospinal fluid secretion [GO:0033326],
negative regulation of cell adhesion molecule production [GO:0060354],
renal water absorption [GO:0070295],
cellular response to glucose stimulus [GO:0071333],
cell-cell adhesion [GO:0098609],

Molecular Function:
protein binding [GO:0005515],
water channel activity [GO:0015250],
channel activity [GO:0015267],
identical protein binding [GO:0042802],

Cellular Component:
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
endosome membrane [GO:0010008],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
sarcolemma [GO:0042383],
astrocyte end-foot [GO:0097450],
endosome [GO:0005768],
cell-cell junction [GO:0005911],
basal plasma membrane [GO:0009925],
membrane [GO:0016020],
T-tubule [GO:0030315],
cell projection membrane [GO:0031253],
macromolecular complex [GO:0032991],
cell projection [GO:0042995],