KMT2A

lysine methyltransferase 2A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
26936960 Pancreas Human, mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
24040009 Human, mouse NO

GO terms:

Biological Process:
transcription from RNA polymerase II promoter [GO:0006366],
apoptotic process [GO:0006915],
positive regulation of transporter activity [GO:0032411],
circadian regulation of gene expression [GO:0032922],
embryonic hemopoiesis [GO:0035162],
histone H4-K16 acetylation [GO:0043984],
histone H3-K4 dimethylation [GO:0044648],
regulation of megakaryocyte differentiation [GO:0045652],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
histone H3-K4 methylation [GO:0051568],
positive regulation of histone H3-K4 methylation [GO:0051571],
macromolecular complex assembly [GO:0065003],
regulation of histone H3-K14 acetylation [GO:0071440],
histone H3-K4 trimethylation [GO:0080182],
histone H3-K4 monomethylation [GO:0097692],
regulation of hematopoietic stem cell differentiation [GO:1902036],
regulation of histone H3-K9 acetylation [GO:2000615],
positive regulation of cellular response to drug [GO:2001040],
DNA methylation [GO:0006306],
chromatin organization [GO:0006325],
regulation of transcription, DNA-templated [GO:0006355],
negative regulation of cell proliferation [GO:0008285],
visual learning [GO:0008542],
response to light stimulus [GO:0009416],
post-embryonic development [GO:0009791],
anterior/posterior pattern specification [GO:0009952],
regulation of gene expression [GO:0010468],
peptidyl-lysine monomethylation [GO:0018026],
methylation [GO:0032259],
exploration behavior [GO:0035640],
regulation of short-term neuronal synaptic plasticity [GO:0048172],
rhythmic process [GO:0048511],
spleen development [GO:0048536],
homeostasis of number of cells within a tissue [GO:0048873],
cognition [GO:0050890],
regulation of histone H3-K4 methylation [GO:0051569],
definitive hemopoiesis [GO:0060216],
regulation of histone H3-K27 acetylation [GO:1901674],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
AT DNA binding [GO:0003680],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
histone methyltransferase activity (H3-K4 specific) [GO:0042800],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
unmethylated CpG binding [GO:0045322],
lysine-acetylated histone binding [GO:0070577],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
methyltransferase activity [GO:0008168],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
histone methyltransferase complex [GO:0035097],
MLL1 complex [GO:0071339],