APPL2

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
diet induced thermogenesis [GO:0002024],
protein import into nucleus [GO:0006606],
cell cycle [GO:0007049],
signal transduction [GO:0007165],
transforming growth factor beta receptor signaling pathway [GO:0007179],
cold acclimation [GO:0009631],
regulation of fibroblast migration [GO:0010762],
signaling [GO:0023052],
adiponectin-activated signaling pathway [GO:0033211],
regulation of toll-like receptor 4 signaling pathway [GO:0034143],
cellular response to hepatocyte growth factor stimulus [GO:0035729],
glucose homeostasis [GO:0042593],
regulation of innate immune response [GO:0045088],
negative regulation of fatty acid oxidation [GO:0046322],
negative regulation of glucose import [GO:0046325],
negative regulation of neurogenesis [GO:0050768],
protein homotetramerization [GO:0051289],
positive regulation of phagocytosis, engulfment [GO:0060100],
negative regulation of cytokine production involved in inflammatory response [GO:1900016],
negative regulation of cellular response to insulin stimulus [GO:1900077],
positive regulation of macropinocytosis [GO:1905303],
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451],
regulation of G1/S transition of mitotic cell cycle [GO:2000045],
negative regulation of neural precursor cell proliferation [GO:2000178],
cell proliferation [GO:0008283],

Molecular Function:
phosphatidylserine binding [GO:0001786],
protein binding [GO:0005515],
phosphatidylinositol binding [GO:0035091],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
macromolecular complex binding [GO:0044877],
Rab GTPase binding [GO:0017137],

Cellular Component:
ruffle [GO:0001726],
nucleus [GO:0005634],
endosome [GO:0005768],
plasma membrane [GO:0005886],
endosome membrane [GO:0010008],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
early endosome membrane [GO:0031901],
vesicle [GO:0031982],
early phagosome [GO:0032009],
ruffle membrane [GO:0032587],
early phagosome membrane [GO:0036186],
macropinosome [GO:0044354],
extracellular exosome [GO:0070062],
cytoplasm [GO:0005737],
cell projection [GO:0042995],