APPL1

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
protein import into nucleus [GO:0006606],
cell cycle [GO:0007049],
signal transduction [GO:0007165],
transforming growth factor beta receptor signaling pathway [GO:0007179],
insulin receptor signaling pathway [GO:0008286],
regulation of fibroblast migration [GO:0010762],
signaling [GO:0023052],
adiponectin-activated signaling pathway [GO:0033211],
regulation of toll-like receptor 4 signaling pathway [GO:0034143],
cellular response to hepatocyte growth factor stimulus [GO:0035729],
regulation of innate immune response [GO:0045088],
regulation of glucose import [GO:0046324],
positive regulation of glucose import [GO:0046326],
positive regulation of melanin biosynthetic process [GO:0048023],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
positive regulation of cytokine production involved in inflammatory response [GO:1900017],
regulation of protein localization to plasma membrane [GO:1903076],
positive regulation of macropinocytosis [GO:1905303],
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905450],
regulation of G1/S transition of mitotic cell cycle [GO:2000045],

Molecular Function:
phosphatidylserine binding [GO:0001786],
protein binding [GO:0005515],
phosphatidylinositol binding [GO:0035091],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein kinase B binding [GO:0043422],
macromolecular complex binding [GO:0044877],
beta-tubulin binding [GO:0048487],

Cellular Component:
ruffle [GO:0001726],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endosome [GO:0005768],
early endosome [GO:0005769],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
endosome membrane [GO:0010008],
vesicle membrane [GO:0012506],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
early endosome membrane [GO:0031901],
early phagosome [GO:0032009],
macropinosome [GO:0044354],
extracellular exosome [GO:0070062],
intracellular vesicle [GO:0097708],
cell projection [GO:0042995],