KIT

KIT proto-oncogene, receptor tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30854802 Primary progenitor cells derived from heart Human NO
31945054 IMR-90 Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPK activity [GO:0000187],
ovarian follicle development [GO:0001541],
hematopoietic progenitor cell differentiation [GO:0002244],
myeloid progenitor cell differentiation [GO:0002318],
lymphoid progenitor cell differentiation [GO:0002320],
immature B cell differentiation [GO:0002327],
dendritic cell cytokine production [GO:0002371],
mast cell chemotaxis [GO:0002551],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
glycosphingolipid metabolic process [GO:0006687],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
multicellular organism development [GO:0007275],
spermatogenesis [GO:0007283],
spermatid development [GO:0007286],
positive regulation of cell proliferation [GO:0008284],
germ cell migration [GO:0008354],
regulation of cell shape [GO:0008360],
visual learning [GO:0008542],
male gonad development [GO:0008584],
positive regulation of gene expression [GO:0010628],
positive regulation of phospholipase C activity [GO:0010863],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
peptidyl-tyrosine phosphorylation [GO:0018108],
cytokine-mediated signaling pathway [GO:0019221],
stem cell population maintenance [GO:0019827],
lamellipodium assembly [GO:0030032],
hemopoiesis [GO:0030097],
B cell differentiation [GO:0030183],
T cell differentiation [GO:0030217],
erythrocyte differentiation [GO:0030218],
melanocyte differentiation [GO:0030318],
positive regulation of cell migration [GO:0030335],
positive regulation of pseudopodium assembly [GO:0031274],
actin cytoskeleton reorganization [GO:0031532],
mast cell cytokine production [GO:0032762],
positive regulation of kinase activity [GO:0033674],
somatic stem cell population maintenance [GO:0035019],
embryonic hemopoiesis [GO:0035162],
ectopic germ cell programmed cell death [GO:0035234],
hematopoietic stem cell migration [GO:0035701],
megakaryocyte development [GO:0035855],
Fc receptor signaling pathway [GO:0038093],
Kit signaling pathway [GO:0038109],
erythropoietin-mediated signaling pathway [GO:0038162],
regulation of cell proliferation [GO:0042127],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
negative regulation of programmed cell death [GO:0043069],
mast cell degranulation [GO:0043303],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of MAPK cascade [GO:0043410],
pigmentation [GO:0043473],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
tongue development [GO:0043586],
positive regulation of Notch signaling pathway [GO:0045747],
positive regulation of JAK-STAT cascade [GO:0046427],
response to cadmium ion [GO:0046686],
protein autophosphorylation [GO:0046777],
somatic stem cell division [GO:0048103],
positive regulation of long-term neuronal synaptic plasticity [GO:0048170],
digestive tract development [GO:0048565],
stem cell differentiation [GO:0048863],
epithelial cell proliferation [GO:0050673],
detection of mechanical stimulus involved in sensory perception of sound [GO:0050910],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of protein kinase B signaling [GO:0051897],
cell chemotaxis [GO:0060326],
mast cell differentiation [GO:0060374],
mast cell proliferation [GO:0070662],
cellular response to thyroid hormone stimulus [GO:0097067],
melanocyte migration [GO:0097324],
melanocyte adhesion [GO:0097326],
regulation of bile acid metabolic process [GO:1904251],
positive regulation of colon smooth muscle contraction [GO:1904343],
positive regulation of small intestine smooth muscle contraction [GO:1904349],
positive regulation of vascular smooth muscle cell differentiation [GO:1905065],
myeloid leukocyte differentiation [GO:0002573],
protein phosphorylation [GO:0006468],
chemotaxis [GO:0006935],
germ cell development [GO:0007281],
response to radiation [GO:0009314],
phosphorylation [GO:0016310],
cell differentiation [GO:0030154],
intracellular signal transduction [GO:0035556],
developmental pigmentation [GO:0048066],

Molecular Function:
protease binding [GO:0002020],
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
stem cell factor receptor activity [GO:0005020],
protein binding [GO:0005515],
ATP binding [GO:0005524],
cytokine binding [GO:0019955],
SH2 domain binding [GO:0042169],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
fibrillar center [GO:0001650],
acrosomal vesicle [GO:0001669],
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell-cell junction [GO:0005911],
external side of plasma membrane [GO:0009897],
cytoplasmic side of plasma membrane [GO:0009898],
mast cell granule [GO:0042629],
receptor complex [GO:0043235],
cytoplasm [GO:0005737],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],