KDM1A

lysine demethylase 1A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28230862 TSC Mouse NO
29438700 MEF, B16F1, DMCs, A375, WM266.4, SK-MEL-28 Human, mouse NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
alternative mRNA splicing, via spliceosome [GO:0000380],
positive regulation of neuroblast proliferation [GO:0002052],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
protein demethylation [GO:0006482],
blood coagulation [GO:0007596],
regulation of double-strand break repair via homologous recombination [GO:0010569],
positive regulation of neuron projection development [GO:0010976],
cerebral cortex development [GO:0021987],
negative regulation of protein binding [GO:0032091],
histone H3-K9 demethylation [GO:0033169],
positive regulation of histone ubiquitination [GO:0033184],
cellular response to UV [GO:0034644],
histone H3-K4 demethylation [GO:0034720],
positive regulation of chromatin binding [GO:0035563],
neuron maturation [GO:0042551],
negative regulation of DNA binding [GO:0043392],
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433],
negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518],
positive regulation of cell size [GO:0045793],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
guanine metabolic process [GO:0046098],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
negative regulation of histone H3-K4 methylation [GO:0051572],
negative regulation of histone H3-K9 methylation [GO:0051573],
muscle cell development [GO:0055001],
oxidation-reduction process [GO:0055114],
response to fungicide [GO:0060992],
cellular response to cAMP [GO:0071320],
cellular response to gamma radiation [GO:0071480],
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166],
regulation of cellular protein localization [GO:1903827],
positive regulation of neural precursor cell proliferation [GO:2000179],
positive regulation of stem cell proliferation [GO:2000648],
chromatin organization [GO:0006325],
chromatin silencing [GO:0006342],
regulation of transcription, DNA-templated [GO:0006355],
multicellular organism development [GO:0007275],
regulation of primitive erythrocyte differentiation [GO:0010725],
pituitary gland development [GO:0021983],
cell differentiation [GO:0030154],
granulocyte differentiation [GO:0030851],
positive regulation of erythrocyte differentiation [GO:0045648],
positive regulation of megakaryocyte differentiation [GO:0045654],
regulation of neurogenesis [GO:0050767],
negative regulation of neurogenesis [GO:0050768],
neuron projection extension [GO:1990138],

Molecular Function:
RNA polymerase II transcription factor binding [GO:0001085],
p53 binding [GO:0002039],
chromatin binding [GO:0003682],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
oxidoreductase activity [GO:0016491],
enzyme binding [GO:0019899],
ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374],
demethylase activity [GO:0032451],
histone demethylase activity [GO:0032452],
histone demethylase activity (H3-K4 specific) [GO:0032453],
histone demethylase activity (H3-K9 specific) [GO:0032454],
histone demethylase activity (H3-dimethyl-K4 specific) [GO:0034648],
telomeric DNA binding [GO:0042162],
MRF binding [GO:0043426],
flavin adenine dinucleotide binding [GO:0050660],
androgen receptor binding [GO:0050681],
telomeric repeat-containing RNA binding [GO:0061752],
promoter-specific chromatin binding [GO:1990841],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
DNA binding [GO:0003677],
histone demethylase activity (H3-monomethyl-K4 specific) [GO:0034649],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
macromolecular complex [GO:0032991],
DNA repair complex [GO:1990391],