APOE

apolipoprotein E

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
response to reactive oxygen species [GO:0000302],
retinoid metabolic process [GO:0001523],
negative regulation of endothelial cell proliferation [GO:0001937],
response to dietary excess [GO:0002021],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
triglyceride metabolic process [GO:0006641],
cholesterol catabolic process [GO:0006707],
cellular calcium ion homeostasis [GO:0006874],
receptor-mediated endocytosis [GO:0006898],
cytoskeleton organization [GO:0007010],
G-protein coupled receptor signaling pathway [GO:0007186],
nitric oxide mediated signal transduction [GO:0007263],
synaptic transmission, cholinergic [GO:0007271],
long-term memory [GO:0007616],
cholesterol metabolic process [GO:0008203],
gene expression [GO:0010467],
negative regulation of platelet activation [GO:0010544],
negative regulation of endothelial cell migration [GO:0010596],
negative regulation of gene expression [GO:0010629],
positive regulation of cholesterol esterification [GO:0010873],
positive regulation of cholesterol efflux [GO:0010875],
lipid transport involved in lipid storage [GO:0010877],
positive regulation of neuron projection development [GO:0010976],
negative regulation of neuron projection development [GO:0010977],
long-chain fatty acid transport [GO:0015909],
protein import [GO:0017038],
virion assembly [GO:0019068],
cGMP-mediated signaling [GO:0019934],
negative regulation of blood coagulation [GO:0030195],
regulation of axon extension [GO:0030516],
neuron projection development [GO:0031175],
negative regulation of cellular protein metabolic process [GO:0032269],
regulation of Cdc42 protein signal transduction [GO:0032489],
positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805],
cholesterol efflux [GO:0033344],
phospholipid efflux [GO:0033700],
chylomicron remodeling [GO:0034371],
very-low-density lipoprotein particle remodeling [GO:0034372],
low-density lipoprotein particle remodeling [GO:0034374],
high-density lipoprotein particle remodeling [GO:0034375],
chylomicron assembly [GO:0034378],
high-density lipoprotein particle assembly [GO:0034380],
chylomicron remnant clearance [GO:0034382],
high-density lipoprotein particle clearance [GO:0034384],
very-low-density lipoprotein particle clearance [GO:0034447],
locomotory exploration behavior [GO:0035641],
lipoprotein biosynthetic process [GO:0042158],
lipoprotein catabolic process [GO:0042159],
vasodilation [GO:0042311],
cholesterol homeostasis [GO:0042632],
amyloid precursor protein metabolic process [GO:0042982],
regulation of protein complex assembly [GO:0043254],
negative regulation of MAP kinase activity [GO:0043407],
negative regulation of neuron apoptotic process [GO:0043524],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
post-translational protein modification [GO:0043687],
reverse cholesterol transport [GO:0043691],
cellular protein metabolic process [GO:0044267],
positive regulation by host of viral process [GO:0044794],
regulation of innate immune response [GO:0045088],
negative regulation of cholesterol biosynthetic process [GO:0045541],
positive regulation of endocytosis [GO:0045807],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of lipid biosynthetic process [GO:0046889],
intracellular transport [GO:0046907],
regulation of neuronal synaptic plasticity [GO:0048168],
artery morphogenesis [GO:0048844],
negative regulation of protein secretion [GO:0050709],
negative regulation of inflammatory response [GO:0050728],
positive regulation of nitric-oxide synthase activity [GO:0051000],
positive regulation of membrane protein ectodomain proteolysis [GO:0051044],
regulation of protein metabolic process [GO:0051246],
maintenance of location in cell [GO:0051651],
fatty acid homeostasis [GO:0055089],
positive regulation of dendritic spine development [GO:0060999],
regulation of proteasomal protein catabolic process [GO:0061136],
response to caloric restriction [GO:0061771],
triglyceride homeostasis [GO:0070328],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
triglyceride-rich lipoprotein particle clearance [GO:0071830],
intermediate-density lipoprotein particle clearance [GO:0071831],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
regulation of cholesterol metabolic process [GO:0090181],
negative regulation of triglyceride metabolic process [GO:0090209],
AMPA glutamate receptor clustering [GO:0097113],
NMDA glutamate receptor clustering [GO:0097114],
cellular oxidant detoxification [GO:0098869],
regulation of beta-amyloid clearance [GO:1900221],
positive regulation of beta-amyloid clearance [GO:1900223],
negative regulation of long-term synaptic potentiation [GO:1900272],
negative regulation of beta-amyloid formation [GO:1902430],
positive regulation of dendritic spine maintenance [GO:1902952],
regulation of amyloid precursor protein catabolic process [GO:1902991],
positive regulation of phospholipid efflux [GO:1902995],
positive regulation of lipid transport across blood brain barrier [GO:1903002],
regulation of behavioral fear response [GO:2000822],
lipid metabolic process [GO:0006629],
lipid transport [GO:0006869],
response to oxidative stress [GO:0006979],
aging [GO:0007568],
protein localization [GO:0008104],
regulation of gene expression [GO:0010468],
axon regeneration [GO:0031103],
lipoprotein metabolic process [GO:0042157],
regulation of apoptotic process [GO:0042981],
positive regulation of axon extension [GO:0045773],
regulation of synapse organization [GO:0050807],
negative regulation of lipid biosynthetic process [GO:0051055],
lipid homeostasis [GO:0055088],
negative regulation of dendritic spine development [GO:0061000],
cardiovascular system development [GO:0072358],
regulation of triglyceride metabolic process [GO:0090207],
negative regulation of cholesterol efflux [GO:0090370],
regulation of plasma lipoprotein particle levels [GO:0097006],
regulation of neuron death [GO:1901214],
negative regulation of neuron death [GO:1901215],
positive regulation of neuron death [GO:1901216],
negative regulation of postsynaptic membrane organization [GO:1901627],
positive regulation of presynaptic membrane organization [GO:1901631],
positive regulation of beta-amyloid formation [GO:1902004],
regulation of tau-protein kinase activity [GO:1902947],
negative regulation of dendritic spine maintenance [GO:1902951],
positive regulation of neurofibrillary tangle assembly [GO:1902998],
negative regulation of phospholipid efflux [GO:1902999],
negative regulation of lipid transport across blood brain barrier [GO:1903001],

Molecular Function:
beta-amyloid binding [GO:0001540],
receptor binding [GO:0005102],
structural molecule activity [GO:0005198],
lipid transporter activity [GO:0005319],
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
heparin binding [GO:0008201],
lipid binding [GO:0008289],
antioxidant activity [GO:0016209],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
heparan sulfate proteoglycan binding [GO:0043395],
macromolecular complex binding [GO:0044877],
metal chelating activity [GO:0046911],
protein dimerization activity [GO:0046983],
tau protein binding [GO:0048156],
low-density lipoprotein particle receptor binding [GO:0050750],
phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228],
very-low-density lipoprotein particle receptor binding [GO:0070326],
lipoprotein particle binding [GO:0071813],
hydroxyapatite binding [GO:0046848],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
early endosome [GO:0005769],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum lumen [GO:0005788],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
membrane [GO:0016020],
dendrite [GO:0030425],
clathrin-coated endocytic vesicle membrane [GO:0030669],
extracellular matrix [GO:0031012],
very-low-density lipoprotein particle [GO:0034361],
low-density lipoprotein particle [GO:0034362],
intermediate-density lipoprotein particle [GO:0034363],
high-density lipoprotein particle [GO:0034364],
discoidal high-density lipoprotein particle [GO:0034365],
chylomicron [GO:0042627],
neuronal cell body [GO:0043025],
synaptic cleft [GO:0043083],
extracellular exosome [GO:0070062],
endocytic vesicle lumen [GO:0071682],
blood microparticle [GO:0072562],
glutamatergic synapse [GO:0098978],
extracellular vesicle [GO:1903561],
lipoprotein particle [GO:1990777],
nuclear envelope [GO:0005635],
lysosome [GO:0005764],
endosome [GO:0005768],
late endosome [GO:0005770],
cytosol [GO:0005829],
microtubule [GO:0005874],
cell surface [GO:0009986],
extrinsic component of external side of plasma membrane [GO:0031232],
synapse [GO:0045202],