KCNJ11

potassium inwardly rectifying channel subfamily J member 11

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31155496 Primary β cells derived from pancreas Mouse YES

GO terms:

Biological Process:
response to ischemia [GO:0002931],
glucose metabolic process [GO:0006006],
response to estradiol [GO:0032355],
response to ATP [GO:0033198],
response to testosterone [GO:0033574],
regulation of ion transmembrane transport [GO:0034765],
regulation of membrane potential [GO:0042391],
response to drug [GO:0042493],
negative regulation of insulin secretion [GO:0046676],
regulation of insulin secretion [GO:0050796],
neurological system process [GO:0050877],
transmembrane transport [GO:0055085],
cellular response to nicotine [GO:0071316],
cellular response to glucose stimulus [GO:0071333],
cellular response to tumor necrosis factor [GO:0071356],
potassium ion transmembrane transport [GO:0071805],
inorganic cation transmembrane transport [GO:0098662],
positive regulation of protein localization to plasma membrane [GO:1903078],
regulation of cardiac conduction [GO:1903779],
potassium ion import across plasma membrane [GO:1990573],
positive regulation of cation channel activity [GO:2001259],
ion transport [GO:0006811],
potassium ion transport [GO:0006813],

Molecular Function:
inward rectifier potassium channel activity [GO:0005242],
voltage-gated potassium channel activity [GO:0005249],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
ATP-activated inward rectifier potassium channel activity [GO:0015272],
cation-transporting ATPase activity [GO:0019829],
ankyrin binding [GO:0030506],
potassium ion binding [GO:0030955],
heat shock protein binding [GO:0031072],
ion channel binding [GO:0044325],
voltage-gated ion channel activity [GO:0005244],

Cellular Component:
acrosomal vesicle [GO:0001669],
nuclear envelope [GO:0005635],
mitochondrion [GO:0005739],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
ATP-sensitive potassium channel complex [GO:0008282],
intercalated disc [GO:0014704],
T-tubule [GO:0030315],
axolemma [GO:0030673],
neuronal cell body [GO:0043025],
myelin sheath [GO:0043209],
cell body fiber [GO:0070852],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
sarcolemma [GO:0042383],
intracellular membrane-bounded organelle [GO:0043231],