potassium voltage-gated channel interacting protein 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
intracellular protein transport [GO:0006886],
apoptotic process [GO:0006915],
signal transduction [GO:0007165],
cardiac conduction [GO:0061337],
potassium ion transmembrane transport [GO:0071805],
protein localization to plasma membrane [GO:0072659],
regulation of potassium ion transmembrane transport [GO:1901379],
ion transport [GO:0006811],
potassium ion transport [GO:0006813],
sensory perception of pain [GO:0019233],
response to magnesium ion [GO:0032026],
regulation of ion transmembrane transport [GO:0034765],
regulation of neuron apoptotic process [GO:0043523],
negative regulation of transcription, DNA-templated [GO:0045892],
response to pain [GO:0048265],
behavioral response to pain [GO:0048266],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
transcription corepressor activity [GO:0003714],
voltage-gated ion channel activity [GO:0005244],
potassium channel activity [GO:0005267],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
potassium channel regulator activity [GO:0015459],
ion channel binding [GO:0044325],
magnesium ion binding [GO:0000287],
core promoter sequence-specific DNA binding [GO:0001046],
protein C-terminus binding [GO:0008022],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],
calcium-dependent protein binding [GO:0048306],

Cellular Component:
nucleus [GO:0005634],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
voltage-gated potassium channel complex [GO:0008076],
dendrite [GO:0030425],
protein-DNA complex [GO:0032993],
axon terminus [GO:0043679],
cytoplasm [GO:0005737],
membrane [GO:0016020],
axon [GO:0030424],