APOC1

apolipoprotein C1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES
31971661 Primary mesenchymal stem cells derived from adipose tissue Mouse YES

GO terms:

Biological Process:
lipid metabolic process [GO:0006629],
triglyceride metabolic process [GO:0006641],
cholesterol metabolic process [GO:0008203],
positive regulation of cholesterol esterification [GO:0010873],
negative regulation of phosphatidylcholine catabolic process [GO:0010900],
negative regulation of very-low-density lipoprotein particle clearance [GO:0010916],
regulation of cholesterol transport [GO:0032374],
negative regulation of cholesterol transport [GO:0032375],
cholesterol efflux [GO:0033344],
phospholipid efflux [GO:0033700],
plasma lipoprotein particle remodeling [GO:0034369],
high-density lipoprotein particle remodeling [GO:0034375],
very-low-density lipoprotein particle assembly [GO:0034379],
chylomicron remnant clearance [GO:0034382],
very-low-density lipoprotein particle clearance [GO:0034447],
lipoprotein metabolic process [GO:0042157],
positive regulation of catalytic activity [GO:0043085],
negative regulation of fatty acid biosynthetic process [GO:0045717],
negative regulation of lipid metabolic process [GO:0045833],
negative regulation of receptor-mediated endocytosis [GO:0048261],
negative regulation of lipid catabolic process [GO:0050995],
negative regulation of lipoprotein lipase activity [GO:0051005],
lipid transport [GO:0006869],

Molecular Function:
phospholipase inhibitor activity [GO:0004859],
fatty acid binding [GO:0005504],
phosphatidylcholine binding [GO:0031210],
lipase inhibitor activity [GO:0055102],
phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228],

Cellular Component:
extracellular region [GO:0005576],
endoplasmic reticulum [GO:0005783],
very-low-density lipoprotein particle [GO:0034361],
high-density lipoprotein particle [GO:0034364],
chylomicron [GO:0042627],