kalirin RhoGEF kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
nervous system development [GO:0007399],
neuromuscular junction development [GO:0007528],
lactation [GO:0007595],
memory [GO:0007613],
adult locomotory behavior [GO:0008344],
vesicle-mediated transport [GO:0016192],
regulation of Rho protein signal transduction [GO:0035023],
social behavior [GO:0035176],
intracellular signal transduction [GO:0035556],
maternal behavior [GO:0042711],
positive regulation of apoptotic process [GO:0043065],
positive regulation of GTPase activity [GO:0043547],
habituation [GO:0046959],
ephrin receptor signaling pathway [GO:0048013],
regulation of small GTPase mediated signal transduction [GO:0051056],
negative regulation of growth hormone secretion [GO:0060125],
maternal process involved in parturition [GO:0060137],
positive regulation of dendritic spine morphogenesis [GO:0061003],
behavioral fear response [GO:0001662],
Rho protein signal transduction [GO:0007266],
axonogenesis [GO:0007409],
response to mechanical stimulus [GO:0009612],
smooth muscle cell migration [GO:0014909],
phosphorylation [GO:0016310],
behavioral response to cocaine [GO:0048148],
regulation of neuronal synaptic plasticity [GO:0048168],
smooth muscle cell proliferation [GO:0048659],
regulation of dendrite development [GO:0050773],
regulation of synaptic transmission, glutamatergic [GO:0051966],
positive regulation of dendritic spine development [GO:0060999],
behavioral response to formalin induced pain [GO:0061368],
modification of postsynaptic actin cytoskeleton [GO:0098885],
NMDA selective glutamate receptor signaling pathway [GO:0098989],
neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645],
positive regulation of long-term synaptic potentiation [GO:1900273],
regulation of protein localization to plasma membrane [GO:1903076],
regulation of modification of postsynaptic actin cytoskeleton [GO:1905274],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
ATP binding [GO:0005524],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
protein binding [GO:0005515],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
enzyme binding [GO:0019899],
Rac guanyl-nucleotide exchange factor activity [GO:0030676],

Cellular Component:
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
actin cytoskeleton [GO:0015629],
extracellular exosome [GO:0070062],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
postsynaptic density [GO:0014069],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
perinuclear region of cytoplasm [GO:0048471],
presynapse [GO:0098793],
glutamatergic synapse [GO:0098978],