APOA1

apolipoprotein A1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
20059975 THP-1, HDFs Human NO
30452555 Primary stem cells derived from adipose tissue Mouse NO
31945054 IMR-90 Human YES

GO terms:

Biological Process:
retinoid metabolic process [GO:0001523],
regulation of protein phosphorylation [GO:0001932],
endothelial cell proliferation [GO:0001935],
platelet degranulation [GO:0002576],
negative regulation of cytokine production involved in immune response [GO:0002719],
phosphatidylcholine biosynthetic process [GO:0006656],
cholesterol biosynthetic process [GO:0006695],
receptor-mediated endocytosis [GO:0006898],
transforming growth factor beta receptor signaling pathway [GO:0007179],
G-protein coupled receptor signaling pathway [GO:0007186],
integrin-mediated signaling pathway [GO:0007229],
response to nutrient [GO:0007584],
cholesterol metabolic process [GO:0008203],
glucocorticoid metabolic process [GO:0008211],
negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804],
positive regulation of cholesterol esterification [GO:0010873],
positive regulation of cholesterol efflux [GO:0010875],
positive regulation of triglyceride catabolic process [GO:0010898],
negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903],
peripheral nervous system axon regeneration [GO:0014012],
protein oxidation [GO:0018158],
peptidyl-methionine modification [GO:0018206],
regulation of lipid metabolic process [GO:0019216],
lipid storage [GO:0019915],
regulation of intestinal cholesterol absorption [GO:0030300],
cholesterol transport [GO:0030301],
adrenal gland development [GO:0030325],
animal organ regeneration [GO:0031100],
regulation of Cdc42 protein signal transduction [GO:0032489],
cholesterol efflux [GO:0033344],
phospholipid efflux [GO:0033700],
negative regulation of heterotypic cell-cell adhesion [GO:0034115],
chylomicron remodeling [GO:0034371],
very-low-density lipoprotein particle remodeling [GO:0034372],
high-density lipoprotein particle remodeling [GO:0034375],
chylomicron assembly [GO:0034378],
high-density lipoprotein particle assembly [GO:0034380],
high-density lipoprotein particle clearance [GO:0034384],
positive regulation of Rho protein signal transduction [GO:0035025],
lipoprotein metabolic process [GO:0042157],
lipoprotein biosynthetic process [GO:0042158],
response to drug [GO:0042493],
cholesterol homeostasis [GO:0042632],
blood vessel endothelial cell migration [GO:0043534],
response to estrogen [GO:0043627],
post-translational protein modification [GO:0043687],
reverse cholesterol transport [GO:0043691],
cellular protein metabolic process [GO:0044267],
positive regulation of fatty acid biosynthetic process [GO:0045723],
phosphatidylcholine metabolic process [GO:0046470],
positive regulation of lipid biosynthetic process [GO:0046889],
negative regulation of interleukin-1 beta secretion [GO:0050713],
negative regulation of inflammatory response [GO:0050728],
positive regulation of phagocytosis [GO:0050766],
protein stabilization [GO:0050821],
negative chemotaxis [GO:0050919],
positive regulation of lipoprotein lipase activity [GO:0051006],
vitamin transport [GO:0051180],
positive regulation of hydrolase activity [GO:0051345],
positive regulation of stress fiber assembly [GO:0051496],
transmembrane transport [GO:0055085],
phospholipid homeostasis [GO:0055091],
negative regulation of lipase activity [GO:0060192],
negative regulation of cell adhesion molecule production [GO:0060354],
negative regulation of response to cytokine stimulus [GO:0060761],
triglyceride homeostasis [GO:0070328],
ERK1 and ERK2 cascade [GO:0070371],
cholesterol import [GO:0070508],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
positive regulation of phospholipid efflux [GO:1902995],
lipid metabolic process [GO:0006629],
phospholipid metabolic process [GO:0006644],
lipid transport [GO:0006869],
protein localization [GO:0008104],
steroid metabolic process [GO:0008202],
phospholipid transport [GO:0015914],
axon regeneration [GO:0031103],
negative regulation of hydrolase activity [GO:0051346],
positive regulation of transferase activity [GO:0051347],

Molecular Function:
beta-amyloid binding [GO:0001540],
receptor binding [GO:0005102],
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
high-density lipoprotein particle binding [GO:0008035],
cholesterol binding [GO:0015485],
enzyme binding [GO:0019899],
heat shock protein binding [GO:0031072],
phosphatidylcholine binding [GO:0031210],
apolipoprotein receptor binding [GO:0034190],
apolipoprotein A-I receptor binding [GO:0034191],
identical protein binding [GO:0042802],
chemorepellent activity [GO:0045499],
lipase inhibitor activity [GO:0055102],
phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228],
high-density lipoprotein particle receptor binding [GO:0070653],
lipid transporter activity [GO:0005319],
lipid binding [GO:0008289],
lipoprotein particle binding [GO:0071813],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
early endosome [GO:0005769],
endoplasmic reticulum lumen [GO:0005788],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
endocytic vesicle [GO:0030139],
cytoplasmic vesicle [GO:0031410],
very-low-density lipoprotein particle [GO:0034361],
low-density lipoprotein particle [GO:0034362],
intermediate-density lipoprotein particle [GO:0034363],
high-density lipoprotein particle [GO:0034364],
discoidal high-density lipoprotein particle [GO:0034365],
spherical high-density lipoprotein particle [GO:0034366],
secretory granule lumen [GO:0034774],
chylomicron [GO:0042627],
extracellular exosome [GO:0070062],
endocytic vesicle lumen [GO:0071682],
blood microparticle [GO:0072562],
extracellular vesicle [GO:1903561],