ITSN1

intersectin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
exocytosis [GO:0006887],
endocytosis [GO:0006897],
G-protein coupled receptor signaling pathway [GO:0007186],
small GTPase mediated signal transduction [GO:0007264],
brain development [GO:0007420],
protein transport [GO:0015031],
viral process [GO:0016032],
endosomal transport [GO:0016197],
positive regulation of kinase activity [GO:0033674],
cellular protein localization [GO:0034613],
positive regulation of apoptotic process [GO:0043065],
negative regulation of neuron apoptotic process [GO:0043524],
ephrin receptor signaling pathway [GO:0048013],
regulation of small GTPase mediated signal transduction [GO:0051056],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of growth hormone secretion [GO:0060124],
positive regulation of dendritic spine development [GO:0060999],
membrane organization [GO:0061024],
regulation of modification of postsynaptic actin cytoskeleton [GO:1905274],
positive regulation of caveolin-mediated endocytosis [GO:2001288],
regulation of Rho protein signal transduction [GO:0035023],
intracellular signal transduction [GO:0035556],
synaptic vesicle endocytosis [GO:0048488],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
kinase activator activity [GO:0019209],
binding, bridging [GO:0060090],
proline-rich region binding [GO:0070064],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
metal ion binding [GO:0046872],

Cellular Component:
nuclear envelope [GO:0005635],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
clathrin-coated pit [GO:0005905],
lamellipodium [GO:0030027],
endocytic vesicle [GO:0030139],
presynaptic membrane [GO:0042734],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
calyx of Held [GO:0044305],
recycling endosome [GO:0055037],
apical dendrite [GO:0097440],
intracellular vesicle [GO:0097708],
presynaptic endocytic zone [GO:0098833],
postsynaptic actin cytoskeleton [GO:0098871],
glutamatergic synapse [GO:0098978],
nucleus [GO:0005634],
endosome [GO:0005768],
membrane [GO:0016020],
cell junction [GO:0030054],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],
neuron projection [GO:0043005],
synapse [GO:0045202],