integrin subunit beta 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
17964297 HUVEC Human NO
20509141 HUVEC Artery Human, mouse NO
21678067 CCCL-1 Human NO
29548335 Saos-2 Human YES
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
24265816 U-251 MG, U-118 MG, T98G, U-87 MG Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
30636108 HBEC, A549, NCI-H1299, Calu-6, NCI-H46 Human NO

GO terms:

Biological Process:
autophagy [GO:0006914],
cell adhesion [GO:0007155],
cell-matrix adhesion [GO:0007160],
integrin-mediated signaling pathway [GO:0007229],
response to wounding [GO:0009611],
cell migration [GO:0016477],
extracellular matrix organization [GO:0030198],
hemidesmosome assembly [GO:0031581],
cell adhesion mediated by integrin [GO:0033627],
nail development [GO:0035878],
skin morphogenesis [GO:0043589],
mesodermal cell differentiation [GO:0048333],
cell motility [GO:0048870],
cell communication [GO:0007154],
myelination in peripheral nervous system [GO:0022011],
peripheral nervous system myelin formation [GO:0032290],
filopodium assembly [GO:0046847],
trophoblast cell migration [GO:0061450],

Molecular Function:
G-protein coupled receptor binding [GO:0001664],
integrin binding [GO:0005178],
protein binding [GO:0005515],
insulin-like growth factor I binding [GO:0031994],
neuregulin binding [GO:0038132],

Cellular Component:
nucleolus [GO:0005730],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
integrin complex [GO:0008305],
cell surface [GO:0009986],
cell junction [GO:0030054],
hemidesmosome [GO:0030056],
cell leading edge [GO:0031252],
nuclear membrane [GO:0031965],
receptor complex [GO:0043235],
extracellular exosome [GO:0070062],
basement membrane [GO:0005604],
cytoplasm [GO:0005737],
cell cortex [GO:0005938],
basal plasma membrane [GO:0009925],
membrane [GO:0016020],
integral component of membrane [GO:0016021],