ITGAM

integrin subunit alpha M

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31155234 heart heart Human NO

GO terms:

Biological Process:
microglial cell activation [GO:0001774],
receptor-mediated endocytosis [GO:0006898],
phagocytosis, engulfment [GO:0006911],
cell adhesion [GO:0007155],
integrin-mediated signaling pathway [GO:0007229],
ectodermal cell differentiation [GO:0010668],
cytokine-mediated signaling pathway [GO:0019221],
extracellular matrix organization [GO:0030198],
forebrain development [GO:0030900],
positive regulation of superoxide anion generation [GO:0032930],
toll-like receptor 4 signaling pathway [GO:0034142],
neutrophil degranulation [GO:0043312],
positive regulation of neutrophil degranulation [GO:0043315],
innate immune response [GO:0045087],
negative regulation of dopamine metabolic process [GO:0045963],
leukocyte migration [GO:0050900],
positive regulation of protein targeting to membrane [GO:0090314],
apoptotic signaling pathway [GO:0097190],
beta-amyloid clearance [GO:0097242],
cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742],
positive regulation of neuron death [GO:1901216],
positive regulation of microglial cell mediated cytotoxicity [GO:1904151],
cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114],
positive regulation of prostaglandin-E synthase activity [GO:2000363],
neutrophil apoptotic process [GO:0001781],
leukocyte migration involved in inflammatory response [GO:0002523],
phagocytosis [GO:0006909],
leukocyte cell-cell adhesion [GO:0007159],
microglia development [GO:0014005],
neutrophil chemotaxis [GO:0030593],
cellular extravasation [GO:0045123],
activated T cell proliferation [GO:0050798],
positive regulation of mast cell differentiation [GO:0060376],
leukocyte adhesion to vascular endothelial cell [GO:0061756],
cell-cell adhesion [GO:0098609],
positive regulation of oxidative stress-induced neuron death [GO:1903223],

Molecular Function:
beta-amyloid binding [GO:0001540],
complement component C3b binding [GO:0001851],
integrin binding [GO:0005178],
protein binding [GO:0005515],
heat shock protein binding [GO:0031072],
cargo receptor activity [GO:0038024],
metal ion binding [GO:0046872],
opsonin binding [GO:0001846],
heparin binding [GO:0008201],
heparan sulfate proteoglycan binding [GO:0043395],
macromolecular complex binding [GO:0044877],

Cellular Component:
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
integrin complex [GO:0008305],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
integrin alphaM-beta2 complex [GO:0034688],
specific granule membrane [GO:0035579],
plasma membrane raft [GO:0044853],
extracellular exosome [GO:0070062],
tertiary granule membrane [GO:0070821],
nucleus [GO:0005634],
integral component of membrane [GO:0016021],