IRF8

interferon regulatory factor 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31676687 RAW 264.7 Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
immune system process [GO:0002376],
phagocytosis [GO:0006909],
autophagy [GO:0006914],
immune response [GO:0006955],
myeloid cell differentiation [GO:0030099],
positive regulation of interferon-gamma production [GO:0032729],
positive regulation of interleukin-12 production [GO:0032735],
defense response to bacterium [GO:0042742],
defense response to protozoan [GO:0042832],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
interferon-gamma-mediated signaling pathway [GO:0060333],
type I interferon signaling pathway [GO:0060337],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interferon-gamma [GO:0071346],
regulation of transcription, DNA-templated [GO:0006355],
response to bacterium [GO:0009617],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
protein binding [GO:0005515],
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],