IRAK4

interleukin 1 receptor associated kinase 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
cytokine production [GO:0001816],
toll-like receptor signaling pathway [GO:0002224],
neutrophil mediated immunity [GO:0002446],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
JNK cascade [GO:0007254],
cytokine-mediated signaling pathway [GO:0019221],
toll-like receptor 9 signaling pathway [GO:0034162],
intracellular signal transduction [GO:0035556],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
innate immune response [GO:0045087],
positive regulation of smooth muscle cell proliferation [GO:0048661],
interleukin-1-mediated signaling pathway [GO:0070498],
neutrophil migration [GO:1990266],
immune system process [GO:0002376],
protein phosphorylation [GO:0006468],
signal transduction [GO:0007165],
phosphorylation [GO:0016310],

Molecular Function:
magnesium ion binding [GO:0000287],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
interleukin-1 receptor binding [GO:0005149],
protein binding [GO:0005515],
ATP binding [GO:0005524],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
endosome membrane [GO:0010008],