APH1A

aph-1 homolog A, gamma-secretase subunit

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

GO terms:

Biological Process:
metanephros development [GO:0001656],
membrane protein ectodomain proteolysis [GO:0006509],
Notch signaling pathway [GO:0007219],
Notch receptor processing [GO:0007220],
protein processing [GO:0016485],
membrane protein intracellular domain proteolysis [GO:0031293],
beta-amyloid formation [GO:0034205],
Notch receptor processing, ligand-dependent [GO:0035333],
amyloid precursor protein metabolic process [GO:0042982],
amyloid precursor protein catabolic process [GO:0042987],
positive regulation of apoptotic process [GO:0043065],
positive regulation of catalytic activity [GO:0043085],
cellular protein metabolic process [GO:0044267],
ephrin receptor signaling pathway [GO:0048013],

Molecular Function:
endopeptidase activity [GO:0004175],
protein binding [GO:0005515],
peptidase activity [GO:0008233],

Cellular Component:
mitochondrion [GO:0005739],
early endosome [GO:0005769],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
synaptic vesicle [GO:0008021],
endosome membrane [GO:0010008],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
Golgi cisterna membrane [GO:0032580],
gamma-secretase complex [GO:0070765],
integral component of presynaptic membrane [GO:0099056],
synaptic membrane [GO:0097060],