interleukin 1 receptor associated kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
32997307 INS-1 832/13, primary mesenchymal cells derived from umbilical cord Human No
32997307 INS-1 832/13, primary mesenchymal cells derived from umbilical cord rat No

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
regulation of cytokine-mediated signaling pathway [GO:0001959],
toll-like receptor signaling pathway [GO:0002224],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
protein phosphorylation [GO:0006468],
activation of NF-kappaB-inducing kinase activity [GO:0007250],
JNK cascade [GO:0007254],
aging [GO:0007568],
viral process [GO:0016032],
cytokine-mediated signaling pathway [GO:0019221],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
positive regulation of type I interferon production [GO:0032481],
response to lipopolysaccharide [GO:0032496],
toll-like receptor 2 signaling pathway [GO:0034134],
toll-like receptor 4 signaling pathway [GO:0034142],
toll-like receptor 9 signaling pathway [GO:0034162],
cellular response to heat [GO:0034605],
intracellular signal transduction [GO:0035556],
negative regulation of apoptotic process [GO:0043066],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of MAP kinase activity [GO:0043406],
innate immune response [GO:0045087],
protein autophosphorylation [GO:0046777],
positive regulation of smooth muscle cell proliferation [GO:0048661],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
type I interferon signaling pathway [GO:0060337],
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423],
interleukin-1-mediated signaling pathway [GO:0070498],
response to interleukin-1 [GO:0070555],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to hypoxia [GO:0071456],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996],
immune system process [GO:0002376],
signal transduction [GO:0007165],
phosphorylation [GO:0016310],
response to peptidoglycan [GO:0032494],
positive regulation of JUN kinase activity [GO:0043507],
negative regulation of transcription, DNA-templated [GO:0045892],
negative regulation of cholesterol efflux [GO:0090370],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
NF-kappaB-inducing kinase activity [GO:0004704],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
heat shock protein binding [GO:0031072],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
nucleotide binding [GO:0000166],
interleukin-1 receptor binding [GO:0005149],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
lipid particle [GO:0005811],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
endosome membrane [GO:0010008],
macromolecular complex [GO:0032991],
membrane [GO:0016020],