APEX2

apurinic/apyrimidinic endodeoxyribonuclease 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
base-excision repair [GO:0006284],
DNA recombination [GO:0006310],
cell cycle [GO:0007049],
nucleic acid phosphodiester bond hydrolysis [GO:0090305],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
DNA binding [GO:0003677],
DNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906],
endonuclease activity [GO:0004519],
phosphodiesterase I activity [GO:0004528],
zinc ion binding [GO:0008270],
double-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008311],
lyase activity [GO:0016829],
nuclease activity [GO:0004518],
exonuclease activity [GO:0004527],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
fibrillar center [GO:0001650],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
intracellular membrane-bounded organelle [GO:0043231],
intracellular [GO:0005622],
cytoplasm [GO:0005737],
mitochondrial inner membrane [GO:0005743],