IQGAP1

IQ motif containing GTPase activating protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90, primary epithelial cells derived from kidney Human YES
32592713 VSMCs Human NO

GO terms:

Biological Process:
regulation of cytokine production [GO:0001817],
signal transduction [GO:0007165],
epidermal growth factor receptor signaling pathway [GO:0007173],
regulation of mitotic cell cycle [GO:0007346],
fibroblast growth factor receptor signaling pathway [GO:0008543],
fibroblast migration [GO:0010761],
viral process [GO:0016032],
cell migration [GO:0016477],
regulation of actin cytoskeleton organization [GO:0032956],
negative regulation of GTPase activity [GO:0034260],
negative regulation of dephosphorylation [GO:0035305],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
neutrophil degranulation [GO:0043312],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of GTPase activity [GO:0043547],
positive regulation of protein kinase activity [GO:0045860],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
positive regulation of focal adhesion assembly [GO:0051894],
cellular response to calcium ion [GO:0071277],
cellular response to epidermal growth factor stimulus [GO:0071364],
glomerular visceral epithelial cell development [GO:0072015],
positive regulation of dendrite development [GO:1900006],
positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086],
positive regulation of cellular protein localization [GO:1903829],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
neuron projection extension [GO:1990138],
response to angiotensin [GO:1990776],
regulation of GTPase activity [GO:0043087],
cellular response to fibroblast growth factor stimulus [GO:0044344],

Molecular Function:
MAP-kinase scaffold activity [GO:0005078],
GTPase inhibitor activity [GO:0005095],
GTPase activator activity [GO:0005096],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547],
Ras GTPase binding [GO:0017016],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
protein domain specific binding [GO:0019904],
small GTPase binding [GO:0031267],
protein serine/threonine kinase activator activity [GO:0043539],
S100 protein binding [GO:0044548],
cadherin binding [GO:0045296],
Rac GTPase binding [GO:0048365],
actin filament binding [GO:0051015],
mitogen-activated protein kinase binding [GO:0051019],
binding, bridging [GO:0060090],
Rho GTPase binding [GO:0017048],
macromolecular complex binding [GO:0044877],

Cellular Component:
ruffle [GO:0001726],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
microtubule [GO:0005874],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
microtubule cytoskeleton [GO:0015630],
lateral plasma membrane [GO:0016328],
axon [GO:0030424],
growth cone [GO:0030426],
midbody [GO:0030496],
secretory granule membrane [GO:0030667],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
slit diaphragm [GO:0036057],
cytoplasmic ribonucleoprotein granule [GO:0036464],
neuron projection [GO:0043005],
membrane raft [GO:0045121],
extracellular exosome [GO:0070062],
ribonucleoprotein complex [GO:1990904],
cell-cell junction [GO:0005911],
membrane [GO:0016020],
cell leading edge [GO:0031252],
macromolecular complex [GO:0032991],