APEX1

apurinic/apyrimidinic endodeoxyribonuclease 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
19492297 BMSCs Bone marrow Human NO
29750271 BJ, GM5565, GM969 Human NO

GO terms:

Biological Process:
telomere maintenance [GO:0000723],
DNA repair [GO:0006281],
base-excision repair [GO:0006284],
base-excision repair, base-free sugar-phosphate removal [GO:0006286],
DNA recombination [GO:0006310],
aging [GO:0007568],
negative regulation of smooth muscle cell migration [GO:0014912],
regulation of apoptotic process [GO:0042981],
regulation of mRNA stability [GO:0043488],
cell redox homeostasis [GO:0045454],
oxidation-reduction process [GO:0055114],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to cAMP [GO:0071320],
cellular response to peptide hormone stimulus [GO:0071375],
DNA demethylation [GO:0080111],
RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502],
telomere maintenance via base-excision repair [GO:0097698],
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087],
negative regulation of nucleic acid-templated transcription [GO:1903507],
positive regulation of nucleic acid-templated transcription [GO:1903508],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
DNA binding [GO:0003677],
damaged DNA binding [GO:0003684],
double-stranded telomeric DNA binding [GO:0003691],
transcription coactivator activity [GO:0003713],
transcription corepressor activity [GO:0003714],
RNA binding [GO:0003723],
DNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906],
endonuclease activity [GO:0004519],
endodeoxyribonuclease activity [GO:0004520],
RNA-DNA hybrid ribonuclease activity [GO:0004523],
phosphodiesterase I activity [GO:0004528],
uracil DNA N-glycosylase activity [GO:0004844],
protein binding [GO:0005515],
phosphoric diester hydrolase activity [GO:0008081],
double-stranded DNA exodeoxyribonuclease activity [GO:0008309],
double-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008311],
3'-5' exonuclease activity [GO:0008408],
oxidoreductase activity [GO:0016491],
lyase activity [GO:0016829],
site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890],
chromatin DNA binding [GO:0031490],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
NF-kappaB binding [GO:0051059],
nuclease activity [GO:0004518],
endoribonuclease activity [GO:0004521],
exonuclease activity [GO:0004527],
hydrolase activity [GO:0016787],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
centrosome [GO:0005813],
ribosome [GO:0005840],
nuclear speck [GO:0016607],
perinuclear region of cytoplasm [GO:0048471],
intracellular [GO:0005622],