INPP5K

inositol polyphosphate-5-phosphatase K

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
in utero embryonic development [GO:0001701],
negative regulation of protein phosphorylation [GO:0001933],
regulation of glycogen biosynthetic process [GO:0005979],
negative regulation of protein kinase activity [GO:0006469],
G-protein coupled receptor signaling pathway [GO:0007186],
negative regulation of peptidyl-threonine phosphorylation [GO:0010801],
negative regulation of glucose transport [GO:0010829],
dephosphorylation [GO:0016311],
response to insulin [GO:0032868],
cellular response to insulin stimulus [GO:0032869],
cellular response to hormone stimulus [GO:0032870],
negative regulation of peptidyl-serine phosphorylation [GO:0033137],
negative regulation of dephosphorylation [GO:0035305],
positive regulation of urine volume [GO:0035810],
glucose homeostasis [GO:0042593],
negative regulation of MAP kinase activity [GO:0043407],
negative regulation by host of viral transcription [GO:0043922],
negative regulation of glycogen biosynthetic process [GO:0045719],
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
negative regulation of insulin receptor signaling pathway [GO:0046627],
inositol phosphate dephosphorylation [GO:0046855],
phosphatidylinositol dephosphorylation [GO:0046856],
negative regulation of stress fiber assembly [GO:0051497],
negative regulation of protein kinase B signaling [GO:0051898],
negative regulation of calcium ion transport [GO:0051926],
cellular response to cAMP [GO:0071320],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to epidermal growth factor stimulus [GO:0071364],
protein localization to plasma membrane [GO:0072659],
negative regulation of protein targeting to membrane [GO:0090315],
ruffle assembly [GO:0097178],
negative regulation of glycogen (starch) synthase activity [GO:2000466],
positive regulation of renal water transport [GO:2001153],
phosphatidylinositol biosynthetic process [GO:0006661],
actin cytoskeleton organization [GO:0030036],

Molecular Function:
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439],
inositol-polyphosphate 5-phosphatase activity [GO:0004445],
vasopressin receptor activity [GO:0005000],
protein binding [GO:0005515],
inositol bisphosphate phosphatase activity [GO:0016312],
hydrolase activity [GO:0016787],
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485],
phosphatidylinositol trisphosphate phosphatase activity [GO:0034594],
phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595],
inositol trisphosphate phosphatase activity [GO:0046030],
inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658],
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659],
lipid phosphatase activity [GO:0042577],

Cellular Component:
ruffle [GO:0001726],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
trans-Golgi network [GO:0005802],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
ruffle membrane [GO:0032587],
neuron projection [GO:0043005],
perinuclear region of cytoplasm [GO:0048471],