APC regulator of WNT signaling pathway 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
microtubule cytoskeleton organization [GO:0000226],
cell fate specification [GO:0001708],
negative regulation of microtubule depolymerization [GO:0007026],
pattern specification process [GO:0007389],
Wnt signaling pathway [GO:0016055],
cell migration [GO:0016477],
regulation of cell differentiation [GO:0045595],
positive regulation of protein catabolic process [GO:0045732],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
activation of GTPase activity [GO:0090630],

Molecular Function:
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
microtubule binding [GO:0008017],
gamma-catenin binding [GO:0045295],

Cellular Component:
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
cytoplasmic microtubule [GO:0005881],
actin filament [GO:0005884],
microtubule cytoskeleton [GO:0015630],
catenin complex [GO:0016342],
midbody [GO:0030496],
beta-catenin destruction complex [GO:0030877],
lamellipodium membrane [GO:0031258],
filamentous actin [GO:0031941],
intercellular bridge [GO:0045171],
perinuclear region of cytoplasm [GO:0048471],
postsynapse [GO:0098794],