IL6

interleukin 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
20818427 MCF 1A, WI-38 Human, mouse NO
21536657 MEF Mouse NO
22374671 TIG-3 Human NO
23953057 Primary fibroblasts derived from cervix Human NO
24713392 Primary hepatocytes derived from liver Liver Mouse NO
24960204 Primary fibroblasts derived from ear Liver, Intestine Mouse NO
25040935 2BS, BJ, WI-38 Human NO
25412309 MCF7 Human NO
27041570 A278p Human NO
27902467 MtT/S, TtT/S Human NO
28472950 MCF-7, MDA-MB-231, HCA2 Human NO
28857276 Primary biliary epithelial cells derived from liver Human NO
30508396 Primary cells derived from muscle Human NO
30590424 Primary stromovascular fractions derived from adipose tissue Mouse NO
30608861 Primary fibroblasts derived from lung Human NO
30666570 Primary fibroblasts derived from skin Human NO
30684147 Submandibular gland Mouse NO
30773784 Primary osteoclast progenitor cells derived from bone marrow Mouse NO
30801661 HDF Human NO
30854802 Primary progenitor cells derived from heart Human NO
30892080 Primary epithelial cells derived from lung Mouse NO
30898011 HeLa Human NO
30907059 Skin, liver, kidney Mouse NO
30928680 3T3-L1 Mouse NO
30977188 MSC Human YES
30988157 IMR-90 Human YES
30995348 Hep 3B, SMMC-7721, HepG2 Human NO
31080015 Primary stem cells derived from endometrium Uterus Human,Mouse NO
31103748 A549 Human
31124078 Primary fibroblasts derived from foreskin, G08, G09 Human NO
31129096 Primary mesenchymal cells derived from bone marrow Human NO
31152494 AG03513,AG11498 Human NO
31155496 Primary β cells derived from pancreas Pancreas Mouse,Human YES
31160572 Human NO
31182708 Primary fibroblasts derived from skin Skin, intensine, tongue Mouse, rat NO
31183403 IMR-90 Human YES
31184599 WI-38 YES
31186408 OV-90,OV-1369,OV-4453,OV-1946,MDA-MB-231 Human
31189884 MCF7 Human NO
31209047 IMR-90 Human NO
31209329 Primary stromal cells derived from adipose tissue, primary fibroblasts derived from skin Human NO
31219154 MCF10A Human YES
31227697 Primary mesenchymal progenitor cells derived from subcutaneous adipose tissue Human NO
31242426 HFF-2, MCF7 Human YES
31250942 BT-549, MDA‐MB‐231 Human NO
31424120 Primary cytotrophoblast cells derived from placenta Mouse NO
31431479 B16-F1 Human NO
31481734 MDA-MB-231, MDA-MB-157 Human NO
31503007 SMMC-7721, Hep G2 Human NO
31521202 Primary stem cells derived from mesenchyma Human NO
31545444 Astrocytic CRT cells Human NO
31554431 Cochlea Rat NO
31561444 Primary cells derived from pancreas Mouse NO
31578521 Huh-7 Human NO
31578786 MMNK-1 Human NO
31586152 HUVEC Human NO
31595820 MEF Bone marrow Mouse NO
31616512 AML12 Mouse NO
31632967 Primary hematopoietic stem cells derived from bone marrow Mouse NO
31635416 Primary fibroblasts derived from skin Human YES
31646843 Primary astrocytes derived from rat Rat NO
31687975 IMR-90 Human YES
31714004 293T, AG11513, AG03199 Human NO
31725940 Bone Mouse NO
31727161 Brain Human NO
31792920 HUVEC Human NO
31811121 IMR-90 Human NO
31860636 2BS, 293T  Human YES
31880094 Bone Mouse NO
31885770 Primary mesenchymal stells derived from adipose tissue Human NO
31900795 Primary astrocytes derived from brain Mouse NO
31907647 SK-OV-3, A2780 Human NO
31935369 PC-9, HCC827, HCC4006, DFCI243 Human YES
31945125 Primary astrocytes derived from brain Human YES
31964233 Primary mesenchymal stem cells derived from synovium Human NO
31971661 Primary mesenchymal stem cells derived from adipose tissue Mouse YES
31978448 A549 Human NO
31979004 HPVEC Human NO
32001510 IMR-90 Human YES
32075966 IMR-90 Human YES
32158519 HUVEC Human NO
31543366 WA09 Human YES
31799499 IMR-90 Liver, lung, brain Human, mouse NO
31981461 Kidney, liver, adipose tissue, spleen, brain Mouse NO
32427330 Primary mesenchymal stem cells Human NO
31943227 Primary fibroblast derived from oral cavity Human NO
32652764 HCT 116 Human NO
32346137 HUVEC Human NO
32460521 Primary fibroblasts derived from lung Human NO
32466233 TIG-3 Human NO
32671444 MDA-MB-231 Human NO
33227437 Primary chondrocytes Cartilage Human NO
32527988 Intervertebral disc Mouse NO
33154378 Primary mesenchymal stem cells derived from bone Mouse NO
32439976 ARPE-19 Retina Mouse NO
32848846 AECs Mouse NO
32727916 Vessel Rat No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
22521547 HCT 116, A549 Human NO
31542391 Plasma Human NO
32042076 Primary fibroblasts derived from skin Human YES
31543366 Brain Mouse YES
32005663 MCF7, HCT 116 Human NO
32570219 Primary fibroblasts derived from skin Human NO
33266246 WI-38 Human NO
33552258 PANC-1, BxPC-3 Human NO
33352936 HDF Human NO
32611834 Cartilage Human NO
32630281 PC-3 Human NO
32304210 Primary cells derived from adipose tissue Human NO
32523550 HCASMC Human No
33381023 A549 Lung Human NO
32417257 MEF, WI-38 Human NO
33381023 A549 Lung mouse NO
32417257 MEF, WI-38 mouse NO
32973510 Kidney Mouse NO
33341947 Primary osteocytes derived from bone Mouse NO

GO terms:

Biological Process:
neutrophil apoptotic process [GO:0001781],
hepatic immune response [GO:0002384],
neutrophil mediated immunity [GO:0002446],
monocyte chemotaxis [GO:0002548],
positive regulation of acute inflammatory response [GO:0002675],
positive regulation of leukocyte chemotaxis [GO:0002690],
acute-phase response [GO:0006953],
inflammatory response [GO:0006954],
humoral immune response [GO:0006959],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
regulation of vascular endothelial growth factor production [GO:0010574],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of gene expression [GO:0010628],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
negative regulation of lipid storage [GO:0010888],
cytokine-mediated signaling pathway [GO:0019221],
platelet activation [GO:0030168],
endocrine pancreas development [GO:0031018],
neuron projection development [GO:0031175],
response to peptidoglycan [GO:0032494],
positive regulation of chemokine production [GO:0032722],
positive regulation of interleukin-6 production [GO:0032755],
negative regulation of collagen biosynthetic process [GO:0032966],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
maintenance of blood-brain barrier [GO:0035633],
positive regulation of T cell proliferation [GO:0042102],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
positive regulation of MAPK cascade [GO:0043410],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
negative regulation of chemokine biosynthetic process [GO:0045079],
positive regulation of interleukin-17 biosynthetic process [GO:0045380],
negative regulation of fat cell differentiation [GO:0045599],
positive regulation of osteoblast differentiation [GO:0045669],
positive regulation of translation [GO:0045727],
regulation of angiogenesis [GO:0045765],
negative regulation of bone resorption [GO:0045779],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JAK-STAT cascade [GO:0046427],
positive regulation of smooth muscle cell proliferation [GO:0048661],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
negative regulation of neurogenesis [GO:0050768],
defense response to Gram-negative bacterium [GO:0050829],
defense response to Gram-positive bacterium [GO:0050830],
positive regulation of B cell activation [GO:0050871],
positive regulation of immunoglobulin secretion [GO:0051024],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
response to glucocorticoid [GO:0051384],
defense response to virus [GO:0051607],
positive regulation of glial cell proliferation [GO:0060252],
neuron cellular homeostasis [GO:0070050],
glucagon secretion [GO:0070091],
interleukin-6-mediated signaling pathway [GO:0070102],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to lipopolysaccharide [GO:0071222],
T-helper 17 cell lineage commitment [GO:0072540],
positive regulation of extracellular matrix disassembly [GO:0090091],
positive regulation of cytokine production involved in inflammatory response [GO:1900017],
positive regulation of apoptotic DNA fragmentation [GO:1902512],
positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800],
regulation of microglial cell activation [GO:1903978],
positive regulation of STAT cascade [GO:1904894],
positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996],
positive regulation of T-helper 2 cell cytokine production [GO:2000553],
negative regulation of primary miRNA processing [GO:2000635],
negative regulation of interleukin-1-mediated signaling pathway [GO:2000660],
positive regulation of type B pancreatic cell apoptotic process [GO:2000676],
myeloid cell homeostasis [GO:0002262],
negative regulation of protein kinase activity [GO:0006469],
immune response [GO:0006955],
regulation of cell shape [GO:0008360],
response to wounding [GO:0009611],
positive regulation of neuron projection development [GO:0010976],
positive regulation of gliogenesis [GO:0014015],
cellular response to hepatocyte growth factor stimulus [GO:0035729],
T cell activation [GO:0042110],
regulation of cell proliferation [GO:0042127],
positive regulation of protein import into nucleus [GO:0042307],
glucose homeostasis [GO:0042593],
defense response to protozoan [GO:0042832],
regulation of apoptotic process [GO:0042981],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
cell redox homeostasis [GO:0045454],
positive regulation of T-helper 2 cell differentiation [GO:0045630],
positive regulation of neuron differentiation [GO:0045666],
negative regulation of gluconeogenesis [GO:0045721],
positive regulation of DNA replication [GO:0045740],
negative regulation of membrane potential [GO:0045837],
muscle cell cellular homeostasis [GO:0046716],
negative regulation of hormone secretion [GO:0046888],
negative regulation of muscle organ development [GO:0048635],
positive regulation of epithelial cell proliferation [GO:0050679],
negative regulation of cytokine secretion [GO:0050710],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of transmission of nerve impulse [GO:0051971],
branching involved in salivary gland morphogenesis [GO:0060445],
epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
positive regulation of cell proliferation in bone marrow [GO:0071864],
negative regulation of neuron death [GO:1901215],

Molecular Function:
cytokine activity [GO:0005125],
interleukin-6 receptor binding [GO:0005138],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
receptor binding [GO:0005102],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
interleukin-6 receptor complex [GO:0005896],
cytoplasm [GO:0005737],
external side of plasma membrane [GO:0009897],