APAF1

apoptotic peptidase activating factor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C-85 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
kidney development [GO:0001822],
neural tube closure [GO:0001843],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
nervous system development [GO:0007399],
aging [GO:0007568],
response to nutrient [GO:0007584],
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635],
cardiac muscle cell apoptotic process [GO:0010659],
cell differentiation [GO:0030154],
forebrain development [GO:0030900],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
neutrophil degranulation [GO:0043312],
neuron apoptotic process [GO:0051402],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
negative regulation of G0 to G1 transition [GO:0070317],
cellular response to transforming growth factor beta stimulus [GO:0071560],
response to G1 DNA damage checkpoint signaling [GO:0072432],
intrinsic apoptotic signaling pathway [GO:0097193],
regulation of apoptotic DNA fragmentation [GO:1902510],
positive regulation of apoptotic signaling pathway [GO:2001235],
multicellular organism development [GO:0007275],
brain development [GO:0007420],
apoptotic signaling pathway [GO:0097190],

Molecular Function:
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
ATP binding [GO:0005524],
cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656],
heat shock protein binding [GO:0031072],
identical protein binding [GO:0042802],
ADP binding [GO:0043531],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],
secretory granule lumen [GO:0034774],
apoptosome [GO:0043293],
extracellular exosome [GO:0070062],
ficolin-1-rich granule lumen [GO:1904813],
cytoplasm [GO:0005737],