IL4

interleukin 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
23935100 Caki-1, A498, 786-O, SNU-482, SNU-228, and A-74 kidney Human NO
24960204 Primary fibroblasts derived from ear Liver, Intestine Mouse NO
31103748 A549 Human
31635416 Primary fibroblasts derived from skin Human YES

GO terms:

Biological Process:
microglial cell activation [GO:0001774],
innate immune response in mucosa [GO:0002227],
positive regulation of defense response to virus by host [GO:0002230],
negative regulation of acute inflammatory response [GO:0002674],
negative regulation of chronic inflammatory response [GO:0002677],
immune response [GO:0006955],
cholesterol metabolic process [GO:0008203],
positive regulation of cell proliferation [GO:0008284],
positive regulation of gene expression [GO:0010628],
negative regulation of epithelial cell migration [GO:0010633],
positive regulation of macroautophagy [GO:0016239],
cytokine-mediated signaling pathway [GO:0019221],
B cell differentiation [GO:0030183],
positive regulation of cell migration [GO:0030335],
positive regulation of B cell proliferation [GO:0030890],
B cell costimulation [GO:0031296],
positive regulation of interleukin-10 production [GO:0032733],
positive regulation of interleukin-13 production [GO:0032736],
T-helper 2 cell cytokine production [GO:0035745],
type 2 immune response [GO:0042092],
positive regulation of T cell proliferation [GO:0042102],
T cell activation [GO:0042110],
macrophage activation [GO:0042116],
regulation of phosphorylation [GO:0042325],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
negative regulation of tumor necrosis factor biosynthetic process [GO:0042536],
activation of Janus kinase activity [GO:0042976],
myeloid dendritic cell differentiation [GO:0043011],
negative regulation of macrophage activation [GO:0043031],
negative regulation of apoptotic process [GO:0043066],
positive regulation of mast cell degranulation [GO:0043306],
T-helper 2 cell differentiation [GO:0045064],
positive regulation of chemokine biosynthetic process [GO:0045080],
regulation of isotype switching [GO:0045191],
positive regulation of MHC class II biosynthetic process [GO:0045348],
positive regulation of T cell differentiation [GO:0045582],
negative regulation of osteoclast differentiation [GO:0045671],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of receptor-mediated endocytosis [GO:0048260],
positive regulation of isotype switching to IgE isotypes [GO:0048295],
positive regulation of isotype switching to IgG isotypes [GO:0048304],
negative regulation of inflammatory response [GO:0050728],
regulation of immune response [GO:0050776],
positive regulation of mononuclear cell migration [GO:0071677],
dendritic cell differentiation [GO:0097028],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
positive regulation of beta-amyloid clearance [GO:1900223],
positive regulation of myoblast fusion [GO:1901741],
positive regulation of cellular respiration [GO:1901857],
negative regulation of complement-dependent cytotoxicity [GO:1903660],
negative regulation of T-helper 17 cell differentiation [GO:2000320],
negative regulation of endothelial cell apoptotic process [GO:2000352],
positive regulation of eosinophil chemotaxis [GO:2000424],
positive regulation of ATP biosynthetic process [GO:2001171],
positive regulation of interleukin-10 secretion [GO:2001181],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
positive regulation of protein phosphorylation [GO:0001934],
T-helper 1 cell lineage commitment [GO:0002296],
positive regulation of immunoglobulin production [GO:0002639],
autophagy [GO:0006914],
regulation of proton transport [GO:0010155],
positive regulation of activated T cell proliferation [GO:0042104],
B cell activation [GO:0042113],
defense response to protozoan [GO:0042832],
negative regulation of nitric oxide biosynthetic process [GO:0045019],
regulation of inflammatory response [GO:0050727],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
negative regulation of T cell activation [GO:0050868],
positive regulation of B cell activation [GO:0050871],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
negative regulation of white fat cell proliferation [GO:0070351],
positive regulation of reactive oxygen species biosynthetic process [GO:1903428],

Molecular Function:
cytokine activity [GO:0005125],
interleukin-4 receptor binding [GO:0005136],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
cytokine receptor binding [GO:0005126],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
external side of plasma membrane [GO:0009897],