interleukin 1 receptor type 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
inflammatory response [GO:0006954],
immune response [GO:0006955],
cell surface receptor signaling pathway [GO:0007166],
cytokine-mediated signaling pathway [GO:0019221],
positive regulation of interferon-gamma production [GO:0032729],
regulation of inflammatory response [GO:0050727],
interleukin-1-mediated signaling pathway [GO:0070498],
response to interleukin-1 [GO:0070555],
positive regulation of neutrophil extravasation [GO:2000391],
positive regulation of T-helper 1 cell cytokine production [GO:2000556],
positive regulation of interleukin-1-mediated signaling pathway [GO:2000661],
signal transduction [GO:0007165],
response to radiation [GO:0009314],
heat acclimation [GO:0010286],
positive regulation of neuron migration [GO:2001224],

Molecular Function:
protease binding [GO:0002020],
transmembrane signaling receptor activity [GO:0004888],
interleukin-1 receptor activity [GO:0004908],
interleukin-1, Type I, activating receptor activity [GO:0004909],
platelet-derived growth factor receptor binding [GO:0005161],
protein binding [GO:0005515],
interleukin-1 binding [GO:0019966],
NAD(P)+ nucleosidase activity [GO:0050135],
hydrolase activity [GO:0016787],
ionotropic glutamate receptor binding [GO:0035255],

Cellular Component:
extracellular region [GO:0005576],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
membrane [GO:0016020],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cell surface [GO:0009986],
postsynaptic density [GO:0014069],
integral component of membrane [GO:0016021],
axon [GO:0030424],
macromolecular complex [GO:0032991],