IL1B

interleukin 1 beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
23385065 BJ Human NO
29548335 Li Fraumeni Human YES
30156862 Primary fibroblasts derived from cornea Human NO
30508396 Primary cells derived from muscle Human NO
30854802 Primary progenitor cells derived from heart Human NO
30907059 Skin, liver, kidney Mouse NO
30968547 Primary epithelial cells derived from thymus Mouse NO
30988157 IMR-90 Human YES
31103748 A549 Human
31152494 AG03513,AG11498 Human NO
31182708 Primary fibroblasts derived from skin Skin, intensine, tongue Mouse, rat NO
31183403 IMR-90 Human YES
31186408 OV-90,OV-1369, OV-1946 Human YES
31219154 MCF10A Human YES
31237151 SW1353, Caco-2 Human NO
31242426 HFF-2  Human YES
31424120 Primary cytotrophoblast cells derived from placenta Mouse NO
31442231 Muscle Mouse NO
31464599 Primary fibroblasts derived from lung Human NO
31543366 WA09 Human YES
31546610 Primary cells dericed from heart Human NO
31554431 Cochlea Rat NO
31595820 MEF Bone marrow Mouse NO
31616512 AML12 Mouse NO
31653055 MCF10A, MCF 7, AGS Human NO
31687975 IMR-90 Human YES
31725940 Bone Mouse NO
31727161 Brain Human NO
31727865 Primary mesenchymal cells derived from bone marrow, Hs-27A Human NO
31799499 IMR-90 Liver Human, mouse NO
31819167 TIG-3 Human NO
31857155 Primary macrophages derived from peritoneum, EO771 Mouse NO
31880094 Bone Mouse NO
31907647 SK-OV-3, A2780 Human NO
31940439 Human NO
31945125 Primary astrocytes derived from brain Human YES
31964233 Primary mesenchymal stem cells derived from synovium Human NO
31981461 Primary peripheral blood CD3 + T lymphocytes Mouse NO
32001510 IMR-90 Human YES
32158519 HUVEC Human NO
31981461 Kidney, liver, adipose tissue, spleen, brain Mouse NO
32622876 Primary chondrocytes derived from cartilage Human No
32346137 HUVEC Human NO
32466233 TIG-3 Human NO
33470505 brain Mouse No
33313981 Primary macrophages derived from kidney Mouse No
32527988 Intervertebral disc Mouse NO
31915373 Hheart_LV_VS healthy Cardiomyocyte Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30977188 MSC Human YES
33381023 A549 Lung Human, mouse NO
32570219 Primary fibroblasts derived from skin Human NO
32611834 Cartilage Human NO
32630281 LNCaP Human NO
32523550 HCASMC Human No
32973510 Kidney Mouse NO
33341947 Primary osteocytes derived from bone Mouse NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPK activity [GO:0000187],
fever generation [GO:0001660],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of T cell mediated immunity [GO:0002711],
apoptotic process [GO:0006915],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
cell-cell signaling [GO:0007267],
embryo implantation [GO:0007566],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
response to carbohydrate [GO:0009743],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of gene expression [GO:0010628],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
negative regulation of glucose transport [GO:0010829],
smooth muscle adaptation [GO:0014805],
cytokine-mediated signaling pathway [GO:0019221],
hyaluronan biosynthetic process [GO:0030213],
positive regulation of cell migration [GO:0030335],
neutrophil chemotaxis [GO:0030593],
sequestering of triglyceride [GO:0030730],
positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949],
positive regulation of prostaglandin biosynthetic process [GO:0031394],
positive regulation of fever generation [GO:0031622],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
positive regulation of prostaglandin secretion [GO:0032308],
response to lipopolysaccharide [GO:0032496],
interleukin-1 beta production [GO:0032611],
interleukin-6 production [GO:0032635],
positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725],
positive regulation of interferon-gamma production [GO:0032729],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of interleukin-8 production [GO:0032757],
positive regulation of immature T cell proliferation in thymus [GO:0033092],
positive regulation of histone phosphorylation [GO:0033129],
response to ATP [GO:0033198],
positive regulation of heterotypic cell-cell adhesion [GO:0034116],
positive regulation of histone acetylation [GO:0035066],
ectopic germ cell programmed cell death [GO:0035234],
positive regulation of myosin light chain kinase activity [GO:0035505],
cellular response to drug [GO:0035690],
positive regulation of T cell proliferation [GO:0042102],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
negative regulation of MAP kinase activity [GO:0043407],
protein kinase B signaling [GO:0043491],
positive regulation of chemokine biosynthetic process [GO:0045080],
positive regulation of interleukin-2 biosynthetic process [GO:0045086],
positive regulation of interleukin-6 biosynthetic process [GO:0045410],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of angiogenesis [GO:0045766],
negative regulation of lipid metabolic process [GO:0045833],
positive regulation of mitotic nuclear division [GO:0045840],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of complement activation [GO:0045917],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
negative regulation of insulin receptor signaling pathway [GO:0046627],
positive regulation of protein export from nucleus [GO:0046827],
astrocyte activation [GO:0048143],
regulation of defense response to virus by host [GO:0050691],
positive regulation of inflammatory response [GO:0050729],
positive regulation of phagocytosis [GO:0050766],
regulation of neurogenesis [GO:0050767],
negative regulation of neurogenesis [GO:0050768],
regulation of insulin secretion [GO:0050796],
negative regulation of synaptic transmission [GO:0050805],
negative regulation of lipid catabolic process [GO:0050995],
positive regulation of lipid catabolic process [GO:0050996],
regulation of nitric-oxide synthase activity [GO:0050999],
positive regulation of membrane protein ectodomain proteolysis [GO:0051044],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of cell division [GO:0051781],
positive regulation of glial cell proliferation [GO:0060252],
positive regulation of cell adhesion molecule production [GO:0060355],
positive regulation of calcidiol 1-monooxygenase activity [GO:0060559],
negative regulation of adiponectin secretion [GO:0070164],
regulation of ERK1 and ERK2 cascade [GO:0070372],
monocyte aggregation [GO:0070487],
interleukin-1-mediated signaling pathway [GO:0070498],
response to interleukin-1 [GO:0070555],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to mechanical stimulus [GO:0071260],
cellular response to organic substance [GO:0071310],
cellular response to organic cyclic compound [GO:0071407],
positive regulation of monocyte chemotactic protein-1 production [GO:0071639],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
positive regulation of p38MAPK cascade [GO:1900745],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of RNA biosynthetic process [GO:1902680],
regulation of establishment of endothelial barrier [GO:1903140],
negative regulation of gap junction assembly [GO:1903597],
positive regulation of T-helper 1 cell cytokine production [GO:2000556],
positive regulation of interleukin-6 secretion [GO:2000778],
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
immune response [GO:0006955],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
memory [GO:0007613],
negative regulation of gene expression [GO:0010629],
positive regulation of cell death [GO:0010942],
negative regulation of glutamate secretion [GO:0014050],
positive regulation of stress-activated MAPK cascade [GO:0032874],
social behavior [GO:0035176],
positive regulation of apoptotic process [GO:0043065],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of JUN kinase activity [GO:0043507],
positive regulation of neuron apoptotic process [GO:0043525],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of glial cell differentiation [GO:0045687],
positive regulation of astrocyte differentiation [GO:0048711],
leukocyte migration [GO:0050900],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of neutrophil chemotaxis [GO:0090023],
negative regulation of branching morphogenesis of a nerve [GO:2000173],
negative regulation of neural precursor cell proliferation [GO:2000178],

Molecular Function:
cytokine activity [GO:0005125],
interleukin-1 receptor binding [GO:0005149],
integrin binding [GO:0005178],
protein binding [GO:0005515],
protein domain specific binding [GO:0019904],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
lysosome [GO:0005764],
cytosol [GO:0005829],
secretory granule [GO:0030141],
cytoplasm [GO:0005737],
cytoplasmic vesicle [GO:0031410],
vesicle [GO:0031982],