AP2A2

adaptor related protein complex 2 subunit alpha 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
intracellular protein transport [GO:0006886],
receptor-mediated endocytosis [GO:0006898],
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886],
low-density lipoprotein particle receptor catabolic process [GO:0032802],
low-density lipoprotein particle clearance [GO:0034383],
neutrophil degranulation [GO:0043312],
ephrin receptor signaling pathway [GO:0048013],
regulation of defense response to virus by virus [GO:0050690],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
membrane organization [GO:0061024],
clathrin-dependent endocytosis [GO:0072583],
endocytosis [GO:0006897],
protein transport [GO:0015031],
vesicle-mediated transport [GO:0016192],
regulation of hematopoietic stem cell differentiation [GO:1902036],

Molecular Function:
molecular_function [GO:0003674],
protein binding [GO:0005515],
lipid binding [GO:0008289],
protein kinase binding [GO:0019901],
clathrin adaptor activity [GO:0035615],
disordered domain specific binding [GO:0097718],
protein domain specific binding [GO:0019904],
phosphatidylinositol binding [GO:0035091],
macromolecular complex binding [GO:0044877],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
AP-2 adaptor complex [GO:0030122],
endocytic vesicle membrane [GO:0030666],
secretory granule membrane [GO:0030667],
clathrin-coated endocytic vesicle membrane [GO:0030669],
cytoplasmic vesicle [GO:0031410],
endolysosome membrane [GO:0036020],
clathrin-coated endocytic vesicle [GO:0045334],
ficolin-1-rich granule membrane [GO:0101003],
clathrin-coated pit [GO:0005905],
synaptic vesicle [GO:0008021],
membrane [GO:0016020],
membrane coat [GO:0030117],
clathrin adaptor complex [GO:0030131],
secretory granule [GO:0030141],