adaptor related protein complex 2 subunit alpha 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
intracellular protein transport [GO:0006886],
Golgi to endosome transport [GO:0006895],
endocytosis [GO:0006897],
receptor-mediated endocytosis [GO:0006898],
positive regulation of neuron projection development [GO:0010976],
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886],
low-density lipoprotein particle receptor catabolic process [GO:0032802],
low-density lipoprotein particle clearance [GO:0034383],
ephrin receptor signaling pathway [GO:0048013],
positive regulation of receptor-mediated endocytosis [GO:0048260],
regulation of defense response to virus by virus [GO:0050690],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
membrane organization [GO:0061024],
clathrin-dependent endocytosis [GO:0072583],
negative regulation of hyaluronan biosynthetic process [GO:1900126],
protein transport [GO:0015031],
vesicle-mediated transport [GO:0016192],

Molecular Function:
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
protein kinase binding [GO:0019901],
clathrin adaptor activity [GO:0035615],
macromolecular complex binding [GO:0044877],
low-density lipoprotein particle receptor binding [GO:0050750],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
AP-2 adaptor complex [GO:0030122],
clathrin coat of trans-Golgi network vesicle [GO:0030130],
endocytic vesicle membrane [GO:0030666],
clathrin-coated endocytic vesicle membrane [GO:0030669],
filopodium tip [GO:0032433],
endolysosome membrane [GO:0036020],
clathrin-coated endocytic vesicle [GO:0045334],
clathrin-coated pit [GO:0005905],
membrane coat [GO:0030117],
clathrin adaptor complex [GO:0030131],
clathrin-coated vesicle [GO:0030136],
secretory granule [GO:0030141],
macromolecular complex [GO:0032991],